** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** INFECTIOUS DISEASE OUTBREAKS CONTINUE TO THREATEN THE HEALTH &AMP; PRODUCTIVITY OF THE US SWINE HERD. THE SEVERITY AND MAGNITUDE OF DISEASE IMPACT DEPEND ON THE INTERACTION OF HERD CHARACTERISTICS AND PRACTICES IMPLEMENTED IN RESPONSE TO OUTBREAKS. EVEN THOUGH VETERINARIANS AND PRODUCERS RECORD ASPECTS RELATED TO DISEASE OUTBREAK RESPONSE &AMP; RECOVERY, THIS DATA IS OFTEN STORED IN DISCONNECTED DATABASES, HAMPERING THE ABILITY TO EXCHANGE KNOWLEDGE, EXPERIENCES, AND DATA-DRIVEN DISCUSSIONS IN THE SWINE INDUSTRY.WE WILL LEVERAGE THE COMBINED EXPERIENCE OF THE WORKING TEAM TO ASSEMBLE A CYBERINFRASTRUCTURE PLATFORM TO STORE AND AGGREGATE DATA FROM HERDS EXPERIENCING DISEASE OUTBREAKS WITH PRRS VIRUS, THE MOST ECONOMICALLY SIGNIFICANT PATHOGEN AFFECTING THE US SWINE HERD. THE MODEL, WHICH CAN LATER BE ADAPTED TO OTHER PATHOGENS AND FOOD ANIMAL SPECIES, WILL REVEAL AND BENCHMARK ASPECTS RELATED TO RESPONSE &AMP; RECOVERY FROM OUTBREAKS. BENCHMARKING EFFORTS WILL FACILITATE DISCUSSIONS WITH VETERINARIANS, PRODUCERS, AND INDUSTRY PARTNERS THAT OFFER RELEVANT PRODUCTS OR TECHNOLOGY TO RESPOND TO DISEASES. REGRESSION AND ARTIFICIAL INTELLIGENCE-BASED ANALYSES WILL FORECAST RECOVERY PARAMETERS, PROVIDE A RECOVERY PROGNOSIS, AND PROVIDE PRODUCER-SPECIFIC DECISION TREES ON BEST PRACTICES FOR SWIFTER RECOVERY FROM OUTBREAKS.STRATEGIC COLLABORATIONS AND EXTENSION ACTIVITIES WILL FOSTER THE PRECISION DISEASE MANAGEMENT CONCEPT. ACTIVITIES WILL PROMOTE THE IMPLEMENTATION OF STRATEGIES AND FIELD-APPLIED KNOWLEDGE TO SUPPORT PRODUCERS IN MAKING DATA-DRIVEN DECISIONS TO EFFICIENTLY IMPROVE RESPONSE &AMP; RECOVERY FROM OUTBREAKS. THE INTEGRATED PROJECT WILL SIGNIFICANTLY IMPROVE THE HEALTH &AMP; PRODUCTIVITY OF THE US SWINE HERD, CREATING THE CAPACITY TO MANAGE EXISTING AND FUTURE ENDEMIC AND EMERGING INFECTIOUS DISEASE THREATS.