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**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FLAVONOIDS ARE A CLASS OF CHEMICAL COMPOUNDS THAT ARE PRESENT IN A VARIETY OF PLANT FOODS AND ARE WIDELY ACCEPTED TO HAVE HEALTH BENEFITS, INCLUDING REDUCING RISK OF CARDIOVASCULAR DISEASE. HOWEVER, THERE ARE DIFFERENCES IN HOW INDIVIDUAL PEOPLE RESPOND TO CONSUMING DIETARY FLAVONOIDS, WHICH CURRENT SCIENCE IS UNABLE TO FULLY EXPLAIN. IT IS POSSIBLE THAT DIFFERENCES IN THE TYPES OR ACTIVITIES OF BACTERIA IN THE GUT MAY INFLUENCE HOW FLAVONOIDS ARE ABSORBED INTO THE BLOODSTREAM, AND THEREFORE MAY EXPLAIN THE DIFFERENT HEALTH BENEFITS EXPERIENCED BY PEOPLE AFTER EATING THEM.THIS STUDY SEEKS TO EXPLAIN PART OF THIS VARIATION. PEOPLE WITH TWO DISTINCT PATTERNS OF A GUT BACTERIA ACTIVITY WILL BE FED A DIET THAT IS CONTROLLED IN CATECHINS (A SPECIFIC TYPE OF FLAVONOID) BY PROVIDING A CONTROLLED AMOUNT OF APPLE JUICE. APPLES ARE A COMMONLY CONSUMED SOURCE OF CATECHINS IN THE AMERICAN DIET. STUDY PARTICIPANTS' URINE WILL BE MONITORED TO DETERMINE WHETHER INDIVIDUALS ARE ABSORBING DIFFERENT FORMS OF CATECHINS AS A RESULT OF GUT BACTERIA ACTIONS, AND THEIR FECES WILL BE MONITORED TO DETERMINE ANY RELATIONSHIP WITH SPECIFIC BACTERIA THAT ARE PRESENT IN THE GUT.IF SUCCESSFUL, THE PROJECT WILL IDENTIFY AN EASILY ACCESSIBLE URINARY BIOMARKER CAPABLE OF PREDICTING WHO WILL HAVE DIFFERENT RESPONSES TO CONSUMING DIETARY FLAVONOIDS. THIS RESULT COULD THEN BE EXPLORED IN FURTHER STUDIES TO DETERMINE IF IT PREDICTS CARDIOVASCULAR HEALTH BENEFITS OF THE CATECHINS AND OTHER FLAVONOIDS. ULTIMATELY, THIS WORK COULD LEAD TO DESIGNING TARGETED DIETS FOR INDIVIDUALS BASED ON A COMBINATION OF BIOMARKER STATUS AND DISEASE RISK.

$636,693FY2023National Institute of Food and AgricultureUSDA

University Of Maryland, College Park, College Park MD

Investigators

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**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** FLAVONOIDS ARE A CLASS OF CHEMICAL COMPOUNDS THAT ARE PRESENT IN A VARIETY OF PLANT FOODS AND ARE WIDELY ACCEPTED TO HAVE HEALTH BENEFITS, INCLUDING REDUCING RISK OF CARDIOVASCULAR DISEASE. HOWEVER, THERE ARE DIFFERENCES IN HOW INDIVIDUAL PEOPLE RESPOND TO CONSUMING DIETARY FLAVONOIDS, WHICH CURRENT SCIENCE IS UNABLE TO FULLY EXPLAIN. IT IS POSSIBLE THAT DIFFERENCES IN THE TYPES OR ACTIVITIES OF BACTERIA IN THE GUT MAY INFLUENCE HOW FLAVONOIDS ARE ABSORBED INTO THE BLOODSTREAM, AND THEREFORE MAY EXPLAIN THE DIFFERENT HEALTH BENEFITS EXPERIENCED BY PEOPLE AFTER EATING THEM.THIS STUDY SEEKS TO EXPLAIN PART OF THIS VARIATION. PEOPLE WITH TWO DISTINCT PATTERNS OF A GUT BACTERIA ACTIVITY WILL BE FED A DIET THAT IS CONTROLLED IN CATECHINS (A SPECIFIC TYPE OF FLAVONOID) BY PROVIDING A CONTROLLED AMOUNT OF APPLE JUICE. APPLES ARE A COMMONLY CONSUMED SOURCE OF CATECHINS IN THE AMERICAN DIET. STUDY PARTICIPANTS' URINE WILL BE MONITORED TO DETERMINE WHETHER INDIVIDUALS ARE ABSORBING DIFFERENT FORMS OF CATECHINS AS A RESULT OF GUT BACTERIA ACTIONS, AND THEIR FECES WILL BE MONITORED TO DETERMINE ANY RELATIONSHIP WITH SPECIFIC BACTERIA THAT ARE PRESENT IN THE GUT.IF SUCCESSFUL, THE PROJECT WILL IDENTIFY AN EASILY ACCESSIBLE URINARY BIOMARKER CAPABLE OF PREDICTING WHO WILL HAVE DIFFERENT RESPONSES TO CONSUMING DIETARY FLAVONOIDS. THIS RESULT COULD THEN BE EXPLORED IN FURTHER STUDIES TO DETERMINE IF IT PREDICTS CARDIOVASCULAR HEALTH BENEFITS OF THE CATECHINS AND OTHER FLAVONOIDS. ULTIMATELY, THIS WORK COULD LEAD TO DESIGNING TARGETED DIETS FOR INDIVIDUALS BASED ON A COMBINATION OF BIOMARKER STATUS AND DISEASE RISK. · GrantIndex