** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** EMERGING AND RE-EMERGING BIOLOGICAL ANIMAL HEALTH THREATS IMPERIL U.S. FOOD SOVEREIGNTY. RAPID DETECTION, RESPONSE, AND RECOVERY OF THREATENING DISEASES REQUIRES A ROBUST AND COORDINATED DIAGNOSTIC INFRASTRUCTURE CORROBORATED WITH ACTIVE MONITORING AND SURVEILLANCE SYSTEMS. THERE IS A UNIQUE OPPORTUNITY TO PURSUE SYNDROMIC SURVEILLANCE USING DATA FROM VETERINARY DIAGNOSTIC LABORATORIES (VDLS). CLOSELY MONITORING CONSOLIDATED VDL DATA ENABLES EARLY DETECTION OF ABNORMAL PATHOGEN ACTIVITY &AMP; RAISES STAKEHOLDERS' AWARENESS. STRATEGIC COLLABORATIONS BETWEEN FIVE NATIONAL ANIMAL HEALTH LABORATORY NETWORK-ACCREDITED VDLS, UNIVERSITIES, AND KEY INDUSTRY STAKEHOLDERS LED TO THE SWINE DISEASE REPORTING SYSTEM (SDRS-HTTPS://WWW.FIELDEPI.ORG/SDRS). THE SDRS NETWORKING CAPABILITY COLLECTS, COLLATES, AND MONITORS DIAGNOSTIC DATA RELATING TO SEVEN INFECTIOUS AGENTS IN U.S. SWINE HERDS. THIS WORK WILL LEVERAGE AND REFINE THE SDRS SYNDROMIC SURVEILLANCE TOOLS TO CREATE AN OPTIMAL SYSTEM FOR ADDRESSING VULNERABILITIES IN DETECTING PATHOGENS THREATENING U.S. SWINE PRODUCTION. EXTENSION AND OUTREACH PRACTICES DEVELOPED IN PARTNERSHIP WITH SWINE STAKEHOLDERS WILL EARLY NOTIFY STAKEHOLDERS OF EMERGING THREATS, ALLOWING RAPID IMPLEMENTATION OF COUNTERMEASURES TO CONTAIN THE FURTHER DISEASE SPREAD IN THE U.S. SWINE POPULATION. EDUCATIONAL EFFORTS WILL TRAIN THE NEXT GENERATION OF STUDENTS AND CULTIVATE FUTURE LEADERS WHO WILL BECOME ENGAGED IN ANIMAL LIVESTOCK PRODUCTION. IN SUMMARY, THIS PROJECT WILL DEVELOP AND IMPLEMENT NEXT-GENERATION SYNDROMIC SURVEILLANCE TOOLS AND CAPABILITIES FOR THE EARLY DETECTION OF IMMINENT THREATENING AGENTS OR DISEASES TO U.S. LIVESTOCK PRODUCTION. RAPID DETECTION AND STAKEHOLDERS' AWARENESS OF EMERGING LIVESTOCK PATHOGENS WILL HELP TO PROTECT OUR FOOD SUPPLY CHAIN AND SOVEREIGNTY.