** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** WHEY WASTE IS A MAJOR CHALLENGE FOR WASTE TREATMENT DUE TO ITS LARGE PRODUCTION GLOBALLY. WHEY CONTAINS KEY NUTRIENT PROTEINS WHICH CAN BE RECOVERED AND VALORIZED AS FOOD PRODUCTS. HOWEVER, RECOVERING HIGH-PURITY FOOD-GRADE PROTEIN FROM WHEY CAN BE VERY CHALLENGING, DUE TO THE COMPLEXITY OF THE WHEY COMPOSITION. CURRENT PROTEIN PURIFICATION TECHNOLOGIES ARE HIGHLY COSTLY STEP FOR WHEY VALORIZATION, DUE TO THE HIGH CONSUMPTION OF CHEMICALS, WATER, AND THE LARGE NUMBER OF SEPARATION PROCESSES REQUIRED. THE DEVELOPMENT OF NEW PURIFICATION TECHNOLOGIES TAILORED AT WHEY PROTEIN RECOVERY CAN GREATLY BENEFIT THE ENVIRONMENT, AGRICULTURE, AND SOCIETY BY PROVIDING A SUSTAINABLE SOURCE OF FOOD PRODUCTS, WHILE AT THE SAME TIME TREATING A MAJOR WASTE OURCE. ELECTROCHEMICALLY-MEDIATED TECHNOLOGIES HAVE THE POTENTIAL TO GREATLY IMPROVE SUSTAINABILITY OF PROTEIN SEPARATIONS BY REMOVING THE NEED FOR REGENERATION CHEMICALS, EXTENSIVE ELUTION, OR THERMAL INPUT.REDOX-ELECTRODIALYSIS CAN PROVIDE A MODULAR PLATFORM FOR WHEY PROTEIN VALORIZATION, DUE TO THE USE OF LOW VOLTAGE - ALLOWING FOR CONTROL OF PH, LOW ENERGY-CONSUMPTION, AND SELECTIVE RECOVERY. HERE, WE SEEK TO DEVELOP A MODULAR, MOLECULARLY-SELECTIVE SYSTEM FOR THE RECOVERY OF WHEY PROTEINS FROM ACID, SWEET, AND SALTY WHEY, THROUGH DESALINATION OF THE INORGANIC SALTS AND THE PURIFICATION OF VALUABLE NUTRIENT PROTEINS. WE DESIGN A NEW MODULAR MEMBRANE-ELECTRODE ARRANGEMENT FOR MULTICOMPONENT RECOVERY, AND STUDY THE STRUCTURE-FUNCTION RELATIONSHIP OF SIZE AND CHARGE OF PROTEINS WITH SELECTIVITY. FINALLY, WE SEEK TO IMPROVE THE ROBUSTNESS OF THE REDOX-FLOW MOIETY TO ELIMINATE CROSSOVER AND ENABLE LONG-TERM OPERATION. THE COMBINATION OF THESE TASKS WILL LEAD TO A MODULAR, ENERGY AND RESOURCE EFFICIENT METHOD FOR PRODUCING VALUABLE FOOD PRODUCTS FROM WHEY STREAMS. OUR PROJECT INVOLVES A CLOSE PARTNERSHIP WITH FOOD MANUFACTURING END-USERS, INCLUDING DAIRY MANUFACTURERS AND FOOD WASTE.