**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** UDDER HEALTH AFFECTS THE YIELD AND QUALITY OF MILK AND, CONSEQUENTLY, CHEESE PRODUCTION AND QUALITY. IN MILK WITH HIGH SOMATIC CELL COUNT (SCC), THE DETERIORATION OF CHEESE-MAKING PROPERTIES OCCURS. THE RELATIONSHIP BETWEEN BACTERIAL INFECTION, INFLAMMATORY RESPONSE, PROTEOLYSIS OF CASEIN AND, CONSEQUENTLY, CHEESE YIELD AND QUALITY ARE COMPLICATED. MILK FROM MASTITIC UDDERS EXHIBITS INCREASED PROTEOLYTIC ACTIVITY. OUR GOAL IS TO MEASURE THE IMMUNE CELL PROFILES AND EXPRESSION OF INFLAMMATORY CYTOKINES IN MILK LEUCOCYTES USING FLOW CYTOMETRY AND ELISA. OUR CENTRAL HYPOTHESIS IS THAT INTRAMAMMARY INFUSION WITH A NOVEL MICRONIZED LACTOFERRIN-SULFONYL-METHANE COMPLEX (GRAS) MIGHT HELP IN THE ELIMINATION AND/OR PREVENTION OF NEW INFECTION BY E. COLI, STAPH. AUREUS, STAPH. CHROMOGENES, STREP. UBERIS, AND/OR STREP. AGALACTIAE SUB-CLINICAL MASTITIS, THEREBY RESULTING IN ENHANCED MILK QUANTITY AND QUALITY. THE WORK PROPOSED MAY REDUCE THE USE OF ANTIBIOTICS IN MILK PRODUCTION SYSTEMS AND ADVANCE THE SCIENCE IN THE IMPORTANT AREA OF REDUCING INTRAMAMMARY INFECTIONS AND PROBLEMATIC LESIONS.