** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** CLOSTRIDIAL DERMATITIS (CD) IN TURKEYS REMAINS ONE OF THE MOST IMPORTANT DISEASES IN TURKEY PRODUCTION. THIS BACTERIAL DISEASE REQUIRES THE MAJORITY OF ANTIBIOTIC USE IN TURKEY PRODUCTION. UNFORTUNATELY, EFFECTIVE CD PREVENTION MEASURES ARE IMPERFECT AND DIFFICULT TO IMPLEMENT, AND THUS THE U.S. TURKEY INDUSTRY IS CHALLENGED TO REDUCE THE ANTIBIOTIC THERAPY THIS DISEASE REQUIRES. TO HELP THE U.S. TURKEY INDUSTRY REDUCE THE NEED FOR ANTIBIOTICS, WE MUST FIND WAYS OF REDUCING THE INCIDENCE OF CLOSTRIDIAL DERMATITIS. HOWEVER, WE WILL NEVER ELIMINATE THIS DISEASE ENTIRELY, AND THEREFORE WE MUST ALSO HELP VETERINARIANS ENSURE THEY ARE PRACTICING GOOD ANTIBIOTIC STEWARDSHIP WHEN TREATMENT IS NEEDED.WE BELIEVE THAT THE ONLY WAY WE WILL SEE MAJOR IMPROVEMENTS IN ANTIBIOTIC STEWARDSHIP AND CONSEQUENT REDUCTIONS IN ANTIBIOTIC RESISTANCE ASSOCIATED WITH TURKEY WILL BE THROUGH A HIGHLY INTEGRATED COLLABORATION WITH THE U.S. TURKEY INDUSTRY. THIS PROJECT WAS DESIGNED IN COLLABORATION WITH VETERINARIANS AT MANY OF THE LARGEST TURKEY COMPANIES IN THE U.S. THE COMPANIES THAT WILL PARTICIPATE IN THIS PROJECT PRODUCE MORE THAN 75% OF TURKEY ANNUALLY IN THE U.S.ONE OF THE OUTCOMES OF THIS PROJECT IS TO DEVELOP DYNAMIC WEB-BASED DASHBOARD TOOLS THAT WILL ENABLE INDUSTRY COLLABORATORS TO EVALUATE OPTIONS FOR REDUCING THE INCIDENCE OF CLOSTRIDIAL DERMATITIS. THE TOOLS WILL SHOW THE USER OUTCOMES SUCH AS EXPECTED REDUCTIONS IN ANTIBIOTIC RESISTANCE ASSOCIATED WITH EACH INTERVENTION OPTION AS WELL AS THE COSTS ASSOCIATED WITH EACH OF THESE STRATEGIES. TOOLS SUCH AS THESE WILL HELP ENSURE THE LONG-TERM SUSTAINABILITY OF U.S. TURKEY PRODUCTION BECAUSE THE END-USERS OF THESE TOOLS WILL BE ABLE TO IDENTIFY EFFECTIVE INTERVENTIONS THAT HAVE AN EFFECT ON MULTIPLE OUTCOMES OF CONCERN WHILE ALSO MAXIMIZING THE RETURN ON INVESTMENT OF THESE STRATEGIESTHE BEST WAY TO REDUCE THE USE OF ANTIBIOTICS IS TO REDUCE THE NEED FOR ANTIBIOTICS. AS STATED PREVIOUSLY, THE BEST WAY TO REDUCE THE NEED FOR ANTIBIOTICS IN U.S. TURKEY PRODUCTION IS TO DECREASE THE INCIDENCE OF CLINICAL CD. THIS PROJECT IS HIGHLY COLLABORATIVE WITH VETERINARIANS AND OTHER PROFESSIONALS WITHIN THE U.S. TURKEY INDUSTRY AND SHOULD GREATLY IMPROVE OUR UNDERSTANDING OF THE KEY DISEASE THAT NECESSITATES THE MAJORITY OF ANTIBIOTIC USE IN TURKEY PRODUCTION.