** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** IN THE UNITED STATES, RESIDENTIAL AND COMMERCIAL BUILDINGS HAVE RELEASED MORE CO2 THAN THE ENTIRE AGRICULTURE SECTOR. ON THE OTHER HAND, THE CO2 CONCENTRATION IN BUILDINGS CAN INCREASE TO 3000 PPM, A LEVEL THAT CAN PROMOTE PLANT GROWTH. THE GOAL OF THIS PROJECT IS TO ESTABLISH A TESTBED FOR APPLICATIONS OF ADVANCED AI AND SENSOR TECHNOLOGIES TO REDUCE CO2 EMISSION FOR INDOOR AND CONTROLLED ENVIRONMENT AGRICULTURE THROUGH THE RECYCLING OF CO2 GENERATED BY HUMAN ACTIVITIES. THIS PROJECT INCLUDES FIVE SPECIFIC AIMS. (1) SMART GROWTH: DEVELOPING PHENOTYPING PLATFORMS TO MONITOR PLANT GROWTH UNDER ELEVATED CO2 AND ALTERNATIVE NUTRIENTS FROM FOOD WASTE. (2) SMART BUILDING: USING HYBRID LIGHT AND MODELING TO REDUCE ENERGY CONSUMPTION FOR INDOOR AGRICULTURE. (3) SMART HEALTH: DEVELOPING METHODS BASED ON METAGENOMIC SEQUENCING, BIOSENSORS, AND CRISPR TECHNOLOGIES FOR PLANT AND HUMAN PATHOGEN DETECTION; (4) CROSS-CUTTING ACTIVITIES: ECONOMIC MODELING, SURVEYS, AND INTEGRATED MACHINE LEARNING FROM PLANT PHENOTYPIC DATA AND ENVIRONMENTAL DATA; AND (5) OUTREACH, EXTENSION, WORKFORCE TRAINING, AND K-12 EDUCATION. THE I2GROW PROJECT EMPHASIZES BOTH TESTING EXISTING TECHNOLOGIES AND DEVELOPING NEW ONES THAT CAN BENEFIT SMALL- AND MEDIUM-SCALE PRODUCERS. THIS PROJECT INVOLVES A TRANSDISCIPLINARY TEAM OF SCIENTISTS AND ENGINEERS. AN ADVISORY BOARD HAS BEEN ASSEMBLED TO INCLUDE MEMBERS FROM ACADEMIA, INDUSTRY, AND A GOVERNMENT RESEARCH AND TRAINING INSTITUTE TO PROVIDE ANNUAL EVALUATION AND FEEDBACK. THE PROJECT DIRECTLY ADDRESSES THE PROGRAM PRIORITIES ON TESTING CLIMATE-SMART TECHNOLOGIES FOR GHG REDUCTION, EXTENSION ACTIVITIES, AND FORMAL AND NON-FORMAL EDUCATION FOR THE NEXT-GENERATION PRODUCERS.