** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE CURRENT INTERDISCIPLINARY, INTEGRATED PROPOSAL ADDRESSES PROGRAM PRIORITIES PRECISION ANIMAL MANAGEMENT, ANIMAL PRODUCTION SYNERGY, AND SOCIETAL ASPECTS OF ANIMAL WELFARE. RECENTLY, AN INCREASE IN SUDDEN DEATH IN FEEDLOT CATTLE DUE TO CONGESTIVE HEART FAILURE HAS BEEN REPORTED. UNFORTUNATELY, THIS CONDITION CAN ONLY BE DETECTED AFTER DEATH, AND NO TOOLS ARE CURRENTLY AVAILABLE TO DETECT ANIMALS MORE PRONE TO THIS OR OTHER STRESS-RELATED CONDITIONS. OUR LONG-TERM GOAL IS TO INCREASE KNOWLEDGE RELATED TO DEATH IN FEEDLOT CATTLE, DEVELOP TOOLS TO IDENTIFY MORE SUSCEPTIBLE ANIMALS EARLIER AND DEVELOP MANAGEMENT STRATEGIES TO INTERVENE AND ENHANCE SUSTAINABILITY. SPECIFIC OBJECTIVES ARE (1A) DEVELOP ALGORITHMS USING PRECISION LIVESTOCK MONITORING TOOLS TO UNDERSTAND STRESS RESPONSIVENESS IN MEDIUM AND HIGH GROWTH RATE CATTLE FROM WEANING THROUGH FINISHING AND CONSEQUENCES ON CARCASS QUALITY, (1B) ESTABLISH A PRODUCER TRAINING PROGRAM ON USING PRECISION ANIMAL MANAGEMENT TOOLS TO IDENTIFY ANIMALS MORE SUSCEPTIBLE TO STRESS; (2) CHARACTERIZE THE PROTEIN AND METABOLITE PROFILES OF HEART AND LIVER SAMPLES FROM CATTLE WHO DIED DUE TO BOVINE CONGESTIVE HEART FAILURE TO BETTER UNDERSTAND THE BIOCHEMICAL BASIS OF THIS CONDITION; AND (3A) EVALUATE THE SOCIAL AND ECONOMIC DETERMINANTS OF PRECISION LIVESTOCK TOOLS TO MINIMIZE NEGATIVE EFFECTS OF STRESS ON BEEF ANIMALS, (3B) EXTEND KNOWLEDGE AND RECOMMENDATIONS TO EXTENSION OFFICES AND OPERATIONS ON THE USE OF PRECISION TECHNOLOGY FOR DETECTION OF STRESSED ANIMALS. OUR TEAM OF LIFE-, PHYSICAL-, AND SOCIAL SCIENTISTS ARE HIGHLY-QUALIFIED TO ADVANCE KNOWLEDGE AND DEVELOP TOOLS TO MITIGATE THE IMPACT OF STRESS ON CATTLE AND IMPROVE STEWARDSHIP OF NATURAL RESOURCES.