** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) IS THE MOST DETRIMENTAL PATHOGEN FOR THESWINE INDUSTRY. THE HIGH MUTATION RATE OF PRRSV REPRESENTS A BIG CHALLENGE FOR CONTROLLING THIS VIRUS AND IT RAISESTWO IMPORTANT QUESTIONS FOR SWINE PRODUCERS: WHICH PRRSV STRAIN WILL HIT MY FARM NEXT? AND WHICH VACCINE CANBEST PROTECT MY HERD AGAINST IT? CURRENTLY NO TECHNOLOGY CAN ADEQUATELY ANSWER THOSE QUESTIONS. TO OVERCOMETHIS ISSUE, THIS PROJECT WILL COMBINE TWO STATE-OF-THE-ART TECHNOLOGIES - PRRSV FORECASTING AND HETEROLOGOUSVACCINE EFFICACY PREDICTION. THESE TECHNOLOGIES WILL CREATE THE FIRST PROACTIVE PRRSV MITIGATION SYSTEM: PREDICTAND PROTECT AGAINST PRRSV (PREPROPRRSV). THEREBY, FOR THE FIRST TIME, PRRSV OUTBREAK MITIGATION WILL BECOMEPROACTIVE!WE WILL ESTABLISH THE PREPROPRRSV SYSTEM IN TWO INTEGRATED OBJECTIVES:OBJECTIVE 1 WILL ESTABLISH A PRRSV STRAIN SPECIFIC FORECASTING TECHNOLOGY. THIS FORECASTING METHODOLOGY USESCOMPUTER-BASED PREDICTION ALGORITHMS BASED ON SURVEILLANCE DATA RELEVANT TO PREDICT PRRSV PROPAGATION VIASEVERAL MODE OF BETWEEN-FARM TRANSMISSION. THIS TECHNOLOGY IS EXPECTED TO PREDICT THE SPREAD OF PRRSV STRAINS.OBJECTIVE 2 WILL ESTABLISH A VACCINE EFFICACY PREDICTION SYSTEM. THIS SYSTEM CONSISTS OF AN IMMUNE BIOBANK (CELLS+ SERUM) FROM PIGS, WHICH RECEIVED DIFFERENT PRRSV VACCINATIONS. THIS BIOBANK WILL ENABLE US TO DETERMINEWITHIN AROUND TWO WEEKS WHICH VACCINE INDUCES THE STRONGEST IMMUNE RESPONSE TO THE APPROACHING PRRSVSTRAIN.THIS INTERDISCIPLINARY PROJECT COMBINES COMPUTER-ALGORITHM-BASED FORECASTING WITH TRANSLATIONAL IMMUNOLOGY TOENABLE PRECISION ANIMAL MANAGEMENT FOR PRRSV: IT WILL DETERMINE THE MOST EFFECTIVE VACCINE BEFORE THEEMERGING PRRSV STRAIN ARRIVES AT A PRODUCTION SITE.THE PROACTIVE PREPROPRRSV OUTBREAK MITIGATION SYSTEM WILL DRASTICALLY ENHANCE ANIMAL HEALTH AND PRODUCTION BYDECREASING THE IMPACT OF PRRS.