**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** THE US IS A GLOBAL PLAYER IN PORK PRODUCTION. THE EFFICIENCY OF PRODUCTION IS DAMPENED BY THE BACTERIUMSTREPTOCOCCUS SUIS, WHICH IS CARRIED BY MOST PIGS. THE RATIONALE OF THIS RESEARCH PROGRAM IS TO DEVELOP NOVEL ANTIMICROBIAL STRATEGIES INDEPENDENT OF ANTIBIOTICS. OUR OVERARCHING HYPOTHESIS IS THAT DELIVERY OF ENGINEERED BACTERIAL VIRUSES OR THEIR PRODUCTS, WILL KILLSTREPTOCOCCUS SUIS, AND LAY A FOUNDATION FOR NOVEL TREATMENT STRATEGIES OFS. SUIS. WE AIM TO ACCOMPLISH OUR OBJECTIVES BY IDENTIFYING AND OPTIMIZING GENE PRODUCTS OF BACTERIAL VIRUSES THAT INFECTS. SUIS, WHICH WILL BE USED TO DEVELOP BENEFICIAL BACTERIA THAT DELIVER THESE GENE PRODUCTS. SUCCESSFUL COMPLETION OF THE PROPOSED WORK WILL DELIVER AN INNOVATIVE STRATEGY TO COMBATS. SUISINDEPENDENT OF ANTIBIOTIC AND VACCINATION TREATMENT, WHICH HAS HAD LIMITED SUCCESS. THE PROPOSED WORK IS IMPORTANT BECAUSE IT CAN POTENTIALLY REDUCE THE USE OF ANTIBIOTICS IN AGRICULTURE TO LOWER ANTIBIOTIC-RESISTANT BACTERIA SELECTION ULTIMATELY. THESE APPROACHES ARE EXPECTED TO IMPROVE ANIMAL WELFARE AND FARM SUSTAINABILITY.