RESPIRATORY INFECTIONS REPRESENT A SIGNIFICANT DISEASE BURDEN ON GOAT PRODUCTION IN THE U.S., HOWEVER, THE SINGLE ANTIBIOTIC LABELED FOR TREATMENT OF RESPIRATORY DISEASE IN GOATS IS NOT EFFECTIVEFOR ALL RESPIRATORY PATHOGENS AFFECTING THIS SPECIES. VETERINARIANS AND PRODUCERS ARE THUS FREQUENTLYFACED WITH THE NEED TO TREAT ANIMALS FOR RESPIRATORY DISEASE WITH ANTIBIOTICS LABELED IN OTHER SPECIESTHAT LACK EFFECTIVENESS AND ESTABLISHED MEAT WITHDRAWALDATA IN GOATS.DUE TO THE SMALL SHARE OF THE MARKET THAT MINOR USESPECIES SUCH AS GOATS REPRESENT IN THE U.S., THERE IS UNFORTUNATELY A LACK OF FINANCIAL INCENTIVE FORDRUG MANUFACTURERS TO PURSUE LABEL CLAIMS FOR THESE MINOR SPECIES DESPITE THE URGENT NEED. OUR SHORT TERMGOAL IS TO COMPLETE THE RESEARCH NECESSARY FOR ESTABLISHING THE CLINICAL EFFECTIVENESSOF TULATHROMYCIN FOR TREATMENT OF RESPIRATORY DISEASE IN NON-LACTATING GOATS, WHICH REPRESENTS A NECESSARY COMPONENT FORAPPLICATION TO THE U.S. FOOD AND DRUG ADMINISTRAION (FDA) FOR LABEL APPROVAL OF THIS MEDICATION. OUR LONG-TERM GOAL IS TOIMPROVE ANTIBIOTIC TREATMENT OPTIONS AND ANTIMICROBIAL STEWARDSHIP IN MINOR USE SPECIES SUCH ASGOATS. TO ACHIEVETHESEGOALS, OUR RESEARCH TEAM WILL COMPLETE A RANDOMIZED CONTROLLED TRIAL OF NATURALLY OCCURRINGRESPIRATORY DISEASE IN GOATS TO ASSESS THEEFFECTIVENESS OF TULATHROMYCIN FOR THIS CONDITION, DOCUMENT THEBACTERIAL CAUSES OF PNEUMONIA IN NON-LACTATINGGOATS IN THE UNITED STATES, AND COLLECT ANTIMICROBIAL RESISTANCE DATA NECESSARY FOR ESTABLISHMENT OF APPROPRIATE TREATMENT GUIDLELINESFOR RESPIRATORY INFECTIONS IN GOATS. WHEN COMPLETED, WE EXPECT THAT OUR WORK WILL LEAD TO IMPROVED HEALTH AND WELFARE OF NON-LACTATING GOATS THROUGH GENERATION OFDATA SUPPORTING THE EFFECTIVE USE OFTULATHROMYCIN FORTREATMENT OF CLINICAL RESPIRATORY DISEASE.THIS DATA WILL THEN BE USED AS PART OF THE APPLICATION FOR FDA LABEL APPROVAL FOR TULATHROMYCINUSE IN GOATS, WHICH WHEN GRANTED WILL IMPROVEMEAT QUALITY ASSURANCE THROUGH ESTABLISHMENT OF AN APPROPRIATE MEAT WITHDRAWAL TIMEFOR SAFE HARVEST AND HUMAN MEAT CONSUMPTIONFOLLOWING TREATMENT.DATA GENERATED FROM THIS PROJECT WILL ALSO BE UTILIZED TO IMPROVEANTIMICROBIAL STEWARDSHIP THROUGH THE GENERATION OF SPECIES-SPECIFIC RECOMMENDATIONS FOR ANTICIPATED TREATMENT EFFECTIVENESS IN GOATS. BY IMPROVING ANTIMICROBIAL STEWARDSHIP IN A FOOD PRODUCING ANIMAL SPECIES, THIS WORK WILL ALSO ASSIST IN THE EFFORT TO DECREASE THE OVERALL BURDEN OF ANTIMICROBIAL RESISTANCE ACROSS HUMAN AND ANIMAL HEALTH.