**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** AIRBORNE ANIMAL DISEASES ARE DIFFICULT TO CONTAIN IN TODAY'S AGRICULTURAL SETTINGS. TO IMPROVE BIOCONTAINMENT STRATEGIES AND MITIGATE AEROSOL TRANSMISSION OF IMPORTANT SWINE PATHOGENS, WE PROPOSE A MULTITIERED APPROACH TO INVESTIGATE AND OPTIMIZE A NOVEL ELECTROSTATIC PRECIPITATOR (ESP) DESIGN TOWARDS BIOCONTAINING AEROSOL TRANSMITTED SWINE DISEASES. WE HYPOTHESIZE THAT A CUSTOM DESIGNED ESP TECHNOLOGY, BOTH WITH STANDARD WIRE DISCHARGE ELECTRODES TO IONIZE PARTICLES AND DRIVE COLLECTION, AS WELL AS SECONDARY ELECTRODES OPERATED TO PRODUCE REACTIVE OXYGEN SPECIES, WILL ENABLE NEW BIOCONTAINMENT MEASURES TO PROTECT SWINE BARNS FROM AIRBORNE VIRUS TRANSPORT BY THEIR UTILIZATION ON THE AIR INTAKE, AND THEN TRANSMISSION FROM BARNS BY THEIR UTILIZATION ON THE EXHAUST AIR. WE WILL PERFORM ENGINEERING EVALUATIONS OF THE PHYSICAL PERFORMANCE, AND DIRECTLY EXAMINE ESP EFFECTS ON AIRBORNE PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND INFLUENZA A VIRUS (IAV), WHICH ARE TWO OF THE MOST IMPORTANT VIRUSES AFFECTING PIGS IN THE U.S. ANIMAL STUDIES WILL BE USED TO ASSESS THE IMPACT OF THE ESP TECHNOLOGY ON VIRUS AIRBORNE TRANSMISSION BETWEEN INFECTED AND SENTINEL ANIMALS. WE WILL INTEGRATE THESE AIMS WITH EDUCATIONAL AND EXTENSION EFFORTS, INCLUDING THE DEVELOPMENT OF COURSES IN AIRBORNE DISEASE TRANSMISSION, BIOSECURITY AND TECHNOLOGIES, AND PRESENTATION OF WORKSHOPS TO ADVANCE AWARENESS, TECHNICAL UNDERSTANDING, AND USE OF TECHNOLOGIES TO PREVENT THE INTRODUCTION AND DISSEMINATION OF AIRBORNE DISEASES IN ANIMAL POPULATIONS AMONGST PRODUCERS, POLICYMAKERS, AND OTHER STAKEHOLDERS. OUR PROPOSAL WILL ENABLE RAPID RESPONSE TO DISEASES THAT POSE LARGE-SCALE BIOSECURITY THREATS IN ANIMAL PRODUCTION, INCLUDING EXISTING AND IMMINENT THREATS BY MITIGATING DISEASE SPREAD REGIONALLY.