**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** PLANT PATHOGENS ACCOUNT FOR 13% OF CROP LOSS, A MAJOR CAUSE OF FOOD INSECURITY FOR APPROXIMATELY 800MILLION PEOPLE WORLDWIDE. PLANT IMMUNITY IS LIMITED BY THE LACK OF AN ADAPTIVE IMMUNE SYSTEM THATENABLES RECOGNITION OF NEW OR EVOLVED PATHOGENS, A PROBLEM EXACERBATED BY GENETIC HOMOGENIZATION THROUGH CROP DOMESTICATION. FURTHERMORE, THE RESISTANCE PROTEINS INVOLVED IN PLANT IMMUNE RECOGNITIONHAVE PROVEN DIFFICULT TO STUDY BIOCHEMICALLY AND BIOPHYSICALLY, MAKING THE ENGINEERING OF THESE PROTEINS ALL THE MORE CHALLENGING. HERE, WE PROPOSE TO EMPLOY A NOVEL PROTEIN ENGINEERING STRATEGY THAT CAN OVERCOME EXISTING CHALLENGES IN ANALYZING AND ENGINEERING THE RECOGNITION SPECIFICITY OF PLANT IMMUNE RECEPTORS. IF SUCCESSFUL, THIS APPROACH WILL BE TRANSFORMATIVE IN ACCELERATING PLANT IMMUNITY APPLICATIONS TO NEW BIOTIC THREATS AND HELP TO SECURE THE GLOBAL FOOD SUPPLY.