**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** ANTIMICROBIAL RESISTANCE (AMR) IS A SIGNIFICANT PROBLEM IN HEALTH CARE, ANIMAL HEALTH, AND FOOD SAFETY. TO LIMITAMR, THERE IS A NEED FOR ALTERNATIVES TO ANTIBIOTICS TO ENHANCE DISEASE RESISTANCE AND SUPPORT JUDICIOUSANTIBIOTIC USAGE IN ANIMALS AND HUMANS. MUCH LIKE HUMANS, NEONATAL AND JUVENILE FOOD ANIMALS ARE PARTICULARLYSUSCEPTIBLE TO DISEASE, AND METHODS TO ENHANCE DISEASE RESISTANCE IN FOOD ANIMALS WOULD BE DIRECTLYBENEFICIAL AND INFORMATIVE FOR ENHANCING HUMAN HEALTH. IMMUNOMODULATION IS A PROMISING METHOD TO ENHANCEDISEASE RESISTANCE AND PROMOTE ANTIBIOTIC STEWARDSHIP. ONE RAPIDLY EVOLVING FIELD OF IMMUNOMODULATION ISINNATE MEMORY (OR INNATE TRAINING), WHICH RELIES ON CELLULAR EPIGENETIC MODIFICATIONS THAT LEAD TO A HEIGHTENED(IE, TRAINED) RESPONSE FOLLOWING REPEATED MICROBIAL STIMULATION OF INNATE IMMUNE CELLS. OUR OVERALL GOAL IS TOUTILIZE INNATE TRAINING AS AN APPROACH TO ENHANCE DISEASE RESISTANCE IN A MANNER THAT IS HIGHLY RELEVANT TO BOTHAGRICULTURE AND BIOMEDICAL RESEARCH. WE WILL TEST A COMPOUND SHOWN TO BE SAFE IN ANIMALS AND HUMANS FOR IT'S ABILITY TO PROTECT PIGS AND CATTLE AGAINST DISEASES COMMON TO EACH INDUSTRY.