GENOME VARIATION IN LIVESTOCK ANIMALS HAS A SPECIAL PATTERN BECAUSE OF THE BREED STRUCTURE. THIS VARIATION CAUSES A WIDE SPECTRUM OF PHYSIOLOGICAL AND PATHOLOGICAL PHENOTYPES. THIS PROPOSAL WILL DEVELOP A CATALOG OF STRUCTURAL VARIANTS FOR CATTLE BREEDS, AND WILL PRODUCE TOOLS AND WORKFLOWS THAT CAN BE USED FOR MANY AGRICULTURAL GENOMES BEYOND CATTLE. THIS CATALOG, AND THE ASSOCIATED TOOLS AND WORKFLOWS, WILL BENEFIT GENOMIC AND GENETIC BREEDING PROGRAMS AS WELL AS THE STUDY OF DISEASE IN CATTLE.