CHEMICALS OF EMERGING CONCERN (CEC) SUCH AS VETERINARY ANTIBIOTICS AND HORMONES HAVE BEEN EXTENSIVELY USED IN THE US AND GLOBALLY, AND THEIR USAGE WILL LIKELY INCREASE SUBSTANTIALLY IN COMING DECADES. A LARGE PORTION OF CEC IS EXCRETED UNCHANGED INTO THE ENVIRONMENT THROUGH MANURE LAND APPLICATIONS. GIVEN THE IMPORTANCE OF VETERINARY ANTIBIOTICS AND HORMONES TO ANIMAL HUSBANDRY, IT IS IMPERATIVE TO BE ABLE TO PREDICT THE TREATMENT EFFICIENCIES OF THESE CONTAMINANTS IN IMPORTANT WASTE MANAGEMENT PROCESSES FOR REUSE OF THESE NONTRADITIONAL WATER RESOURCES. CURRENTLY, NO PREDICTIVE TOOLS ARE AVAILABLE TO ESTIMATE HOW WELL EXISTING CONTROL TECHNOLOGIES CAN REMOVE CEC IN MANURE.IN THIS PROJECT, WE PROPOSE TO EXAMINE THE DEGRADATION OF 22+ VETERINARY ANTIBIOTICS AND HORMONES (FROM EIGHT GROUPS) IN ANAEROBIC DIGESTION (AD), ONE OF THE BEST MANURE TREATMENT PROCESSES, IN BOTH BATCH AND CONTINUOUS STIRRED-TANK REACTORS. MOREOVER, GIVEN THE INSUFFICIENT REMOVAL OF SOME CEC IN AD, WE PROPOSE TOSIGNIFICANTLY ENHANCE CEC REMOVAL BY THREE ADVANCED OXIDATION PROCESSES BASED ON HYDROXYL AND/OR SULFATE RADICALS AND PERMANGANGE/BISULFITE (A POWERFUL OXIDANT THAT CAN DESTRUCT CEC IN MILLISECONDS) IN EITHER PRE- OR POST-AD TREATMENT. ARMED WITH MACHINE LEARNING AND OTHER ADVANCED MODELING APPROACHES, PREDICTIVE TOOLS WILL BE DEVELOPED BETWEEN THE OBSERVED REACTIVITY IN BOTH AD AND AOPS AND THE CEC STRUCTURES TO ALLOW ESTIMATION OF THE REACTIVITY OF A WIDE RANGE OF CEC IN THESE PROCESSES. RESULTS OF THIS PROJECT WILL RESULT IN MORE REALISTIC ESTIMATES OF THE DISCHARGE OF CEC FROM LIVESTOCK MANURE INTO THE ENVIRONMENT. KNOWING SUCH INFORMATION WILL NOT ONLY ENABLE US TO DEVELOP SUSTAINABLE MANAGEMENT PLANS TO ENSURE THE ENVIRONMENTAL AND HEALTH SAFETY OF THE VAST VOLUME OF MANURE, BUT ALSO ALLOW US TO ASSESS THE ACCURATE RISK OF APPLYING DIFFERENT CEC-CONTAINING MANURES TO FARM LANDS AND THE LIQUID FRACTION OF AD EFFLUENTS FOR IRRIGATION. GREENER AGRICULTURAL PRODUCTS CAN ALSO BE DESIGNED BY KNOWING THE REMOVAL BEHAVIOR OF THE EXISTING PRODUCTS. ULTIMATELY, RESULTS OF THIS PROJECT CAN BE USED BY THE USDA TO IMPROVE U. S. AGRICULTURE AND FOOD SYSTEMS.