**AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** GLOBAL WATER DEMAND IS PROJECTED TO INCREASE BY 55% BETWEEN 2000 AND 2050 AND OVER 40% OF THE WORLD'S POPULATION WILL LIVE UNDER SEVERE WATER STRESS BY THE MIDDLE OF THIS CENTURY. TOGETHER WITH INCREASING WATER DEMAND, WORLDWIDE DEMAND FOR FERTILIZER HAS BEEN INCREASING BY 2.4% PER YEAR AND IS EXPECTED TO REACH 200 MILLION TONS BY 2021. COUPLED WITH DECLINING RESERVES OF PHOSPHATE, AN ESSENTIAL COMPOUND FOR FERTILIZATION, THESE PRESENT THREATS TO GLOBAL FOOD SECURITY. IN THE UNITED STATES, CONCENTRATED ANIMAL FEEDING OPERATIONS SUCH AS SWINE, POULTRY, BEEF, AND DAIRY FARMS PRODUCE MORE THAN 133 MILLION TONS OF LIVESTOCK WASTEWATER EVERY YEAR. BASED ON THEIR ORIGIN, LIVESTOCK WASTEWATER CAN CONTAIN ELEVATED CONCENTRATIONS OF CARBON PHOSPHORUS AND NITROGEN THAT HAVE THE POTENTIAL TO BE RECOVERED AS FERTILIZERS. HOWEVER, THE CURRENT TREATMENT TECHNOLOGIES OF LIVESTOCK WASTEWATER (E.G. ACTIVATED SLUDGE OR TRICKLING FILTER SYSTEMS) ARE NOT DESIGNED FOR RESOURCE RECOVERY AND INADEQUATEFOR SUSTAINING LONG-TERM AGRICULTURAL PRODUCTION, GENERATING A GRADUAL DETERIORATION OF SOIL AND GROUNDWATER PROPERTIES THROUGH THE LOADING OF NITRATE, NITRITE, PHARMACEUTICAL BYPRODUCTS, AND ANTIBIOTIC RESIDUES FROM LIVESTOCK. WITHOUT PROPER TREATMENT, RUNOFF OR RELEASE OF LIVESTOCK WASTEWATER FROM FARMS TO AQUATIC ECOSYSTEMS WAS SHOWN TO CAUSE SEVERE ENVIRONMENTAL IMPACTS, E.G. EUTROPHICATION OF RIVERS, LAKES, AND COASTAL OCEANS, AS WELL AS N2O AND NH3 GAS EMISSIONS THAT POLLUTE THE ATMOSPHERE. THEREFORE, THERE IS A NEED TO TREAT LIVESTOCK WASTEWATER PRIOR TO ITS DISCHARGE WHILE RECOVERING VALUABLE COMPOUNDS SUCH AS WATER AND NUTRIENTS.THE GOAL OF THE PROPOSED EFFORT IS TO TURN LIVESTOCK WASTEWATER TO VALUABLE PRODUCTS INCLUDING HIGH-QUALITY WATER FIT FOR IRRIGATION (I.E. NO BACTERIA AND LOW SALINITY), AMMONIA GAS FOR ENERGY/FERTILIZER PRODUCTION, AND STRUVITE, A SLOW-RELEASE FERTILIZER. TO THIS END, WE WILL DEVELOP A NOVEL SYSTEM BY INTEGRATING MICROBIAL ELECTROLYSIS CELLS, FORWARDOSMOSIS, AND MEMBRANE DISTILLATION. THESE ARE MICROBIOLOGICAL, ELECTROCHEMICAL AND PHYSICAL PROCESSES THAT CAN SYNERGISTICALLY OVERCOME THE INHERENT LIMITATIONS OF EACH OTHER. WE WILL DEMONSTRATE THE FEASIBILITY OF THE PROPOSED SYSTEM BY MONITORING THE SYSTEM PERFORMANCE IN TERMS OF ORGANIC REMOVAL, WATER RECLAMATION, NUTRIENT RECOVERY, ENERGY CONSUMPTION, AND CAPITAL COST. FUNDAMENTAL ASPECTS INCLUDING FOULING BEHAVIORS AND MICROBIAL COMMUNITIES WILL BE STUDIED TO PROVIDE A MECHANISTIC UNDERSTANDING OF THE POTENTIAL AND LIMITATION OF THE SYSTEM. THIS PROJECT IS EXPECTED TO DEVELOP A ROBUST, STABLE AND COST-EFFECTIVE PROCESS FOR RECOVERING SOLID FERTILIZER AND WATER FROM LIVESTOCK WASTEWATER AT LOW ENERGY CONSUMPTION. THE PRODUCED WATER WILL MEET EPA'S REGULATIONS FOR IRRIGATION. FROM A FUNDAMENTAL PERSPECTIVE, WE ANTICIPATE TO GAIN AN IN-DEPTH UNDERSTANDING OF THE MICROBIOLOGY AND FOULING IN THE SYSTEM. THE SYSTEM WILL BE ANALYZED IN TERMS OF CAPITAL AND OPERATION COST AND COMPARED TO ADDITIONAL BIOLOGICAL AND PHYSICAL TREATMENT OPTIONS. OVERALL, THE RESEARCH WILL ADVANCE THE MANAGEMENT OF LIVESTOCK WASTEWATER.