VACCINATION IS CRITICAL FOR THE CONTROL OF INFECTIOUS DISEASES IN FOOD ANIMALS. NEW AND IMPROVED VACCINES ARE NEEDED TO PROTECT ANIMALS FROM EXISTING AND EMERGING INFECTIOUS DISEASES AND TO REDUCE THE NEED FOR ANTIBIOTIC USE IN FOOD ANIMALS. ADJUVANTS ARE ESSENTIAL COMPONENTS OF MANY VACCINES THAT HELP TO GENERATE ROBUST PROTECTIVE IMMUNE RESPONSES. WE DISCOVERED THAT CORN-DERIVED PHYTOGLYCOGEN NANOPARTICLES CAN BE MODIFIED WITH SIMPLE CHEMICAL PROCEDURES TO CREATE INEXPENSIVE AND BIODEGRADABLE PARTICLES THAT HAVE IMMUNOSTIMULATORY PROPERTIES. THE GOAL OF THE RESEARCH IS TO TEST THE UTILITY OF THESE NOVEL NANOPARTICLES AS EFFECTIVE AND SAFE ADJUVANTS FOR A NEW VACCINE AGAINST INFLUENZA IN SWINE. POTENTIAL SYNERGISM BETWEEN THE NANOPARTICLES AND ANOTHER IMMUNOSTIMULATORY COMPOUND, POLY(I:C), WILL BE DETERMINED, AND DIFFERENT ROUTES OF ADMINISTRATION OF THE VACCINE WILL BE TESTED.