OUR PRIMARY RESEARCH GOAL IS TO REDUCE THE RISK OF BOVINE RESPIRATORY DISEASE COMPLEX (BRDC) FOR WESTERN AND MIDWESTERN U.S. DAIRY CATTLE VIA GENETIC IMPROVEMENT. WE HAVE ESTABLISHED MODERATE HERITABILITY ESTIMATES FOR BRDC SUSCEPTIBILITY IN WESTERN HOLSTEIN CALVES, AND HYPOTHESIZE THAT THE SAME WILL BE TRUE FOR 1,000 MIDWESTERN HOLSTEINS SOUGHT FOR THE PRESENT STUDY. LEVERAGING EXISTING DATA (N = 2,800 WESTERN HOLSTEIN CALVES WITH 778K GENOTYPES, BRDC PHENOTYPES, PATHOGEN DIAGNOSTIC DATA CODED FOR ABUNDANCE, GENOME SEQUENCES) AND NEW PRELIMINARY DATA (N = 2,800 WESTERN HOLSTEIN CALVES WITH CUSTOM ILLUMINA10K GENOTYPES, SIRE PREDICTED TRANSMITTING ABILITIES), WE INTEND TO ELICIT BROADER IMPACTS TO THE U.S. DAIRY INDUSTRY BY DETERMINING IF MODERATE OR LARGE-EFFECT BRDC QUANTITATIVE TRAIT LOCI (QTL) ARE TRANSLATIONAL ACROSS TWO U.S. DAIRY INTENSIVE REGIONS (I.E., WESTERN, MIDWESTERN). IN DOING SO, WE ALSO CREATE AN OPPORTUNITY TO DETECT REGION-SPECIFIC BRDC QTL RESULTING FROM SIGNIFICANT GENOTYPE BY ENVIRONMENT INTERACTIONS. HEREIN, WE WILL PRODUCE POPULATION, REGION, AND META-ANALYSES THAT INCLUDE MARKER-BASED HERITABILITY ESTIMATES, GENOME-WIDE ASSOCIATION ANALYSES (GWAA), ESTIMATES OF GENOTYPE X ENVIRONMENT (GXE) INTERACTIONS, GENOMICALLY ESTIMATED BREEDING VALUES (GEBVS), AND CONCLUDE OUR STUDY BY GENOMICALLY PREDICTING BRDC PHENOTYPES USING CROSS VALIDATION TO ASSESS ACCURACIES. OUR ANALYSES WILL SEEK TO DETERMINE IF GENOMIC PREDICTION SHOULD OCCUR FOR INDIVIDUAL POPULATIONS OR REGIONS (PERHAPS DUE TO SIGNIFICANT GXE INTERACTIONS), OR IF PREDICTION ACCURACY GENERALLY INCREASES WITH INCLUSION OF SEQUENTIALLY LARGER U.S. TRAINING SETS. THIS STUDY TRANSLATES GENOMIC DATA INTO ANIMAL HEALTH BREEDING DECISIONS.