EACH YEAR, BETWEEN 7 AND 11% OF FEMALE CALVES BORN ON US DAIRY FARMS DIE IN THE FIRST 60 DAYS OF LIFE. INFECTIOUS DISEASES SUCH AS PNEUMONIA OR DIARRHEA ACCOUNT FOR 80% OF THESE DEATHS. REPLACING LACTATING COWS REPRESENT 20% OF TOTAL DAIRY PRODUCTION COSTS. HENCE, HEALTH DISORDERS OF YOUNG STOCK SIGNIFICANTLY IMPACT THE SUSTAINABILITY OF THE DAIRY INDUSTRY AND ITS CAPACITY TO MEET FOOD DEMANDS FOR THE GROWING WORLD POPULATION. IN YOUNG CALVES, DISEASE PREVENTION THROUGH VACCINATION IS NOT EFFECTIVE BECAUSE THE IMMUNE RESPONSE TO VACCINES IN THESE ANIMALS DOESN'T PROVIDE EFFECTIVE PROTECTION AT THE HIGHEST RISK PERIOD OF NEONATAL DISEASE. HENCE, NEW STRATEGIES ARE NEEDED TO ALLOW FOR EFFECTIVE VACCINATION PROTOCOLS EARLIER IN THE LIFE OF CALVES. THIS PROJECT WILL EXPLORE HOW SUPPLEMENTATION WITH ANTI-OXIDATIVE MICRONUTRIENTS CAN OPTIMIZE THE IMMUNE RESPONSE TO VACCINES IN YOUNG DAIRY CALVES. A BETTER UNDERSTANDING OF HOW IMMUNITY CAN BE ENHANCED THROUGH NUTRITIONAL INTERVENTIONS MAY LEAD TO IMPROVED DISEASE PREVENTION STRATEGIES, A REDUCTION OF THE ANTIMICROBIAL USAGE, AND OPTIMIZED PRODUCTION EFFICIENCY IN THE US DAIRY INDUSTRY.