IRRIGATION WITH TREATED WASTEWATER AND APPLICATION OF BIOSOLIDS OR ANIMAL WASTE INTRODUCE NUMEROUS CONTAMINANTS OF EMERGING CONCERN (CECS) INTO AGROECOSYSTEMS. ACCUMULATION OF CECS IN FOOD CONSTITUTES A HUMAN HEALTH RISK THROUGH DIETARY EXPOSURE, BUT CEC RISK ASSESSMENT AND MANAGEMENT ARE CONSTRAINED BY THE FACT THAT CECS ARE NUMEROUS IN NUMBER AND DIVERSE IN PHYSICOCHEMICAL PROPERTIES. THE TRADITIONAL, OBSERVATION-BASED APPROACH HAS BEEN LARGELY INFEASIBLE AND INEFFECTIVE. WE PROPOSE TO DEVELOP A MODULAR OR TIERED FRAMEWORK THAT INTEGRATES SIMPLE PROCESS-BASED, QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS (QSPRS) TO DESCRIBE THE CEC FLUX FROM THE INPUT SOURCES (E.G., WWTP EFFLUENT, BIOSOLIDS, ANIMAL WASTE), THROUGH THE SOIL/ROOT INTERFACE, AND INTO LEAVES/FRUITS. BOTH ROOT VEGETABLES AND LEAFY/FRUIT BEARING PLANTS WILL BE CONSIDERED. LITERATURE DATA AS WELL AS EXPERIMENTAL MEASUREMENTS WILL BE USED TO VALIDATE AND REFINE THE SIMPLE PREDICTIVE MODELS. THE MODULAR FRAMEWORK CAN BE USED TO SCREEN AND DERIVE A SHORT LIST OF HIGH RISK CECS THAT EXHIBIT THE GREATEST ACCUMULATION POTENTIAL IN EDIBLE PLANT PARTS, AND TO PREDICT THE RISK OF NEW CECS. THE OUTCOMES OF THIS PROJECT INCLUDE COMPREHENSIVE DATABASES CONTAINING THE CHEMICAL INPUT FLUXES, ANTICIPATED SOIL CONCENTRATIONS, ROOT BIOCONCENTRATION FACTORS, LEAF/FRUIT BIOCONCENTRATION FACTORS, AND POTENTIAL HUMAN EXPOSURE, OF A LARGE NUMBER OF CECS, AND EASY-TO-USE QSPR MODELS. THIS PROJECT PROVIDES A COMMON THREAD FUSING THE CURRENT SCATTERED AND DISJOINTED RESEARCH EFFORTS, THUS OVERCOMING THE BARRIER IN ADDRESSING ISSUES FACING CECS IN AGRICULTURE. FINDINGS CONTRIBUTE TO A SUSTAINABLE U.S. AGRICULTURE BY PROMOTING SAFE REUSE OF TREATED WASTEWATER, BIOSOLIDS, AND ANIMAL WASTE PRODUCTS AS VALUABLE RESOURCES.