THE REDUCTION OF ANTIBIOTIC USE IN ANIMAL AGRICULTURE IN THE UNITED STATES IS A NECESSARY STEP TOWARDS REDUCING THE EMERGENCE AND PERSISTENCE OF ANTIMICROBIAL RESISTANCE IN BACTERIAL PATHOGENS OF HUMANS AND ANIMALS. HOWEVER, REDUCTION OF USE DOES NOT PROMISE REDUCTION OF RESISTANCE, AND THIS APPROACH MAY CREATE ANCILLARY PROBLEMS RELATED TO INCREASED DISEASE-ASSOCIATED MORTALITY. THIS WORK WILL ATTACK THESE PROBLEMS IN A MULTI-PRONGED EFFORT. FIRST, GENETIC TECHNOLOGY WILL BE USED DEVELOP A SYSTEM THAT TARGETS ANTIMICROBIAL RESISTANCE. SECOND, WEB-BASED OPEN ACCESS TOOLS WILL BE DEVELOPED TO EDUCATE POULTRY PRODUCERS ABOUT VACCINATION STRATEGIES AND PROVIDE A SIMPLE WAY TO CHOOSE VACCINE STRAINS. THIRD,PROBIOTICS WILL BE CHARACTERIZED AND EXAMINED IN COMMERCIAL TURKEYS TO DEVELOP BETTER PROBIOTICS. FINALLY, SYMPOSIA AND ONLINE EDUCATIONAL MATERIALS RELATED TO PREBIOTICS AND PROBIOTICS WILL BE DELIVERED TO APPROPRIATE AUDIENCES TO PROVIDE CLARITY TO THE CONFUSING REALM OF ALTERNATIVE FEED ADDITIVE SELECTION AND USE. OVERALL, THIS PROJECT WILL BUILD ON THE FUTURE OF MITIGATION STRATEGIES AGAINST ANTIMICROBIAL RESISTANCE AND WILL PROVIDE EDUCATIONAL AND HANDS-ON TOOLS TO ENABLE SCIENCE-BASED DECISION-MAKING BY THE POULTRY PRODUCER.