THIS PROJECT WILL STUDY A RESPIRATORY DISEASE OF YOUNG CALVES, CALLED RESPIRATORY SYNCYTIAL VIRUS (BRSV). THIS DISEASE IS OFTEN FATAL TO YOUNG CALVES AND MAKES THEM VERY SICK. OLDER CATTLE CAN BE INFECTED ALSO. THERE IS NO GOOD THERAPY AVAILABLE. WE ARE TESTING THE COMMON DRUG IBUPROFEN AND ALSO A NEW DRUG THAT STOPS THE VIRUS FROM GROWING IN THE CALF. WE WILL MEASURE THE SYMPTOM SEVERITY AND WILL EVALUATE HOW BADLY THE LUNGS ARE AFFECTED BY DOING A NECROPSY (ANIMAL VERSION OF AUTOSPSY). WE WILL EVALUATE MANY DIFFERENT CELLS AND TISSUES IN THE CALVES TO DETERMINE HOW THESE DRUGS EFFECT THE REACTION THAT THEY HAVE TO THE VIRAL INFECTION. WE EXPECT THAT THIS WORK WILL LEAD NOT ONLY TO A BETTER WAY TO TREAT BRSV BUT ALSO A BETTER WAY FOR HUMAN DOCTORS TO TREAT THE CLOSELY RELATED DISEASE HUMAN RSV.