THE OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP A PIEZOELECTRIC INSTRUMENT FOR PRECISION EXPLORATION SAMPLING (PIPES). PIPES IS A MINIATURIZED LIQUID SAMPLE ACQUISITION AND HANDLING SYSTEM WHICH LOOKS LIKE A STRAW AND IS POWERED BY A HAND-HELD BOX. THE STRAW CONTAINS MULTIPLE FLOW PATHS FOR PARALLEL SAMPLING. ENABLED BY 3D PRINTING PIPES INTEGRATES ACOUSTIC ACTUATION TO ACHIEVE MULTIPLE SAMPLING FUNCTIONS (E.G. PUMPING FILTERING AND MIXING) IN ONE COMPACT UNIT. THE PIPES SYSTEM SEEKS TO FILL A GAP IN NASA S CURRENT IN-FLIGHT SENSING CAPABILITIES: THE LACK OF MINIATURIZED FLUIDIC SAMPLING AND HANDING SYSTEMS. THE PIPES WILL MAKE DRAMATIC IMPROVEMENTS AT THE SYSTEM LEVEL IN TERMS OF WEIGHT COST AND OPERATIONAL SIMPLICITY. THE SPECIFIC APPLICATION EXPLORED IN THIS PROJECT IS TO PROVIDE A SIMPLE AND RELIABLE TEST OF THE SAFETY OF POTABLE WATER CONSUMED DURING HUMAN EXPLORATION MISSIONS. THE PROOF-OFCONCEPT WILL BE THE DETECTION OF THE BACTERIUM E. COLI IN WATER. ALTHOUGH THE SPACE-FLIGHT APPLICATION IS SPECIALIZED THE NEW TOOL IS A VERSATILE MICRO- TO MESO-SCALE FLUIDIC SAMPLING SYSTEM THAT CAN WORK WITH MULTIPLE MESO- AND MICRO-SCALE DETECTION TECHNOLOGIES SUCH AS ELECTROCHEMICAL SENSORS MICROMACHINED CHROMATOGRAPHS AND MINIATURE MASS SPECTROMETERS. THEREFORE PIPES HAS GREAT CROSSCUTTING POTENTIAL IN BIOMEDICAL AND ENVIRONMENTAL APPLICATIONS. THE STARTING TRL WILL BE 2 SINCE THE KEY PHENOMENA UNDERLYING PIPES HAVE BEEN REPORTED IN PEER REVIEWED JOURNALS BY THE PI AND THE END TRL WILL BE 3 AIMING AT HARDWARE DEMONSTRATION OF PIPES.