THE UNITED NATIONS SUSTAINABLE DEVELOPMENT GOALS TARGET TO ELIMINATE GLOBAL MALARIA EPIDEMICS BY 2030. IN RESPONSE THE WORLD HEALTH ORGANIZATION (WHO) SET FORTH AN AMBITIOUS AND INSPIRING AGENDA FOR GLOBAL MALARIA ELIMINATION WHICH INCLUDES BY 2030 A 90% REDUCTION OF MORTALITY RATES GLOBALLY ELIMINATION OF MALARIA FROM 35 COUNTRIES AND PREVENTION OF RE-ESTABLISHMENT OF MALARIA THAT ARE CURRENTLY MALARIA-FREE (BASED ON THE 2015 MORTALITY RATE AND DISTRIBUTION). CONSIDERABLE PROGRESS HAS BEEN MADE TOWARDS THIS GOAL ACROSS THE WORLD WITH THE MOST SUBSTANTIAL INVESTMENT IN SUB-SAHARAN AFRICA THAT FACES THE GREATEST MALARIA-DRIVEN MORTALITY. HOWEVER THE RECENT EMERGENCE OF ARTEMISININ-RESISTANT POPULATIONS OF PLASMODIUM FALCIPARUM (ONE OF MALARIA CARRYING PARASITES) IN THE GREATER MEKONG SUB-REGION IS POSED NOT ONLY TO SLOW DOWN THE PROGRESS BUT POTENTIALLY UNDERMINE THE ENTIRE ELIMINATION CAMPAIGN BY RENDERING THE MOST EFFICIENT MALARIA TREATMENT AVAILABLE TO DATE INEFFECTIVE. WHO CONSIDERS THE EMERGING ARTEMISININ RESISTANCE A MAJOR HEALTH SECURITY RISK AS NO ALTERNATIVE ANTIMALARIAL MEDICINE IS AVAILABLE AT PRESENT WITH THE SAME LEVEL OF EFFICACY AND TOLERABILITY (HTTP://WWW.WHO.INT/MALARIA/MEDIA/ARTEMISININ_RESISTANCE_QA/EN/).MYANMAR ONE OF THE 5 COUNTRIES WITH DOCUMENTED CASES OF EMERGENCE OF ARTEMISININ RESISTANCE CARRIES A DISPROPORTIONAL MALARIA BURDEN IN THE REGION WITH ~4% OF THE REGION S POPULATION AND 20% OF THE REGION S MALARIA. THROUGH PREVIOUS AND ON-GOING RESEARCH AND INTERVENTION ACTIVITIES MEMBERS OF THE PROPOSING TEAM HAVE ESTABLISHED AN EXTENSIVE NETWORK AND RESEARCH BASE IN MYANMAR AND ARE POISED FOR A STRONG CONTINUING ENGAGEMENT IN MALARIA ELIMINATION WORK THERE. THE PROPOSED APPLICATIONS PROJECT AIMS TO SUPPORT THESE EFFORTS BY DEVELOPING A ROBUST SATELLITE DATA DRIVEN EARLY WARNING SYSTEM TO FORECAST MALARIA HOTSPOTS DYNAMICALLY IN SPACETIME. MYANMAR MALARIA EARLY WARNING SYSTEM (MMEWS) WILL BE DESIGNED TO MOVE THE SATELLITE-BASED MALARIA FORECASTING BEYOND THE NARROW SCOPE OF MONITORING AND FORECASTING VECTOR HABITAT SUITABILITY AND POTENTIAL FOR SURGE IN VECTOR PREVALENCE. THE MALARIA BURDEN POTENTIAL THE PRIMARY SYSTEM OUTPUT IN SUPPORT OF ELIMINATION AND TREATMENT ACTIVITIES IS VIEWED AS A COMBINATION OF ENVIRONMENTAL FACTORS THAT CONTROL VECTOR POPULATIONS AND ENVIRONMENTAL SOCIO-ECONOMIC AND POLITICAL FACTORS THAT CONTROL POPULATION EXPOSURE AND VULNERABILITY. MMEWS WILL FUNCTION WITHIN A FLEXIBLE MULTI-TEMPORAL ASSESSMENT FRAMEWORK WHERE VARIOUS COMPONENTS (E.G. VECTOR ABUNDANCE AND POPULATION VULNERABILITY) HAVE DIFFERENT OPERATIONAL UPDATE PERIODICITY. THE SYSTEM WILL ALSO FOCUS ON OBSERVATIONS OF ENVIRONMENTAL CHANGES WITHIN TARGET LANDSCAPE OBJECTS RATHER THAN INDISCRIMINATELY ACROSS THE REGION AS A WHOLE. FOR EXAMPLE WE WILL BE OBSERVING CHANGES IN WATER EXTENT ONLY WITHIN LANDSCAPE OBJECTS THAT ARE IDENTIFIED IN MMEWS BASE MAP AS THOSE THAT CAN POTENTIALLY CONTAIN WATER (E.G. PERMANENT WATER BODIES EPHEMERAL WATER OBJECTS OR TOPOGRAPHICAL DEPRESSIONS). THIS APPROACH AND DATA FUSION FROM MULTIPLE MODERATE (LANDSAT AND SENTINEL 1 AND 2) AND COARSE (MODIS VIIRS) RESOLUTION OPTICAL AND MICROWAVE SENSORS WILL ALLOW FOR AN 8-DAY SYSTEM UPDATE PERIOD WITH MAPPING PRIMARILY AT MODERATE RESOLUTION THAT IS RELEVANT TO VILLAGE-SCALE ASSESSMENTS. WE BRING TOGETHER A TEAM OF EXPERTS IN OPTICAL AND MICROWAVE REMOTE SENSING SPATIAL ANALYSIS AND MALARIOLOGY TO DEVELOP A SYSTEM THAT WILL SUPPORT MEDICAL INTERVENTION ACTIVITIES. THE PROPOSED SYSTEM WILL BE DEPLOYED IN THE YANGON OFFICE OF THE INSTITUTE FOR GLOBAL HEALTH AND SHARED WIDELY WITH THE REGIONAL PARTNERS AND OTHER INTERESTED ACTORS.