THE COOL TEAM WILL CONDUCT AN INTERDISCIPLINARY INVESTIGATION OF THE ORIGINS EVOLUTION AND SIGNIFICANCE OF TRANSLATION WHICH IS A WINDOW TO PRIMEVAL EVENTS AND MOLECULAR STRUCTURES. WE WILL INTEGRATE BIOPHYSICAL STRUCTURAL BIOINFORMATIC BIOCHEMICAL CHEMICAL AND EVOLUTIONARY APPROACHES TO UNDERSTAND BIOLOGY S INTERNAL FOSSIL RECORD . OUR OVERRIDING SCIENTIFIC QUESTION IS: HOW DID THE ORIGINAL AND MOST PROFOUND MUTUALISTIC RELATIONSHIP IN BIOLOGY OF POLYPEPTIDE AND POLYNUCLEOTIDE TAKE ROOT AND ULTIMATELY COME TO DEFINE AND RULE THE BIOLOGICAL EARTH? THE CENTRAL QUESTION WILL BE FRAMED BY FOUR THEMES: (THEME 1) EVOLUTION OF TRANSLATION IN VIVO (THEME 2) EVOLUTION OF TRANSLATION IN VITRO (THEME 3) WALKING BACK FROM EXTANT BIOLOGY AND (THEME 4) ORIGINS OF MOLECULAR MUTUALISM.

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