THE BETH ISRAEL DEACONESS MEDICAL CENTER (CONTRACTOR) PROPOSAL TITLED TIME COURSE OF SPACEFLIGHT INDUCED ADAPTATIONS IN BONE MORPHOLOGY BONE STRENGTH AND MUSCLE MASS QUALITY WHICH WAS SUBMITTED IN RESPONSE TO NASA S HUMAN EXPLORATION RESEARCH OPPORTUNITY (HERO) NASA RESEARCH ANNOUNCEMENT (NRA) SOLICITATION 80JSC017N0001?BPBA WAS SELECTED FOR DEFINITION IN NOVEMBER 2018. THIS STATEMENT OF WORK COVERS THE ACTIVITIES TO BE PERFORMED BY BETH ISRAEL DEACONESS MEDICAL CENTER AS REQUESTED BY THE NASA PORTFOLIO MANAGER HUMAN HEALTH&COUNTERMEASURES (HHC) ELEMENT. THE PERIOD OF PERFORMANCE (POP) FOR THIS STATEMENT OF WORK IS DIVIDED IN TWO PHASES ? PHASE 1: DEFINITION&PHASE 2: IMPLEMENTATION. THIS INITIAL VERSION ONLY APPLIES TO PHASE 1: DEFINITION. THE CONTRACTOR IS AUTHORIZED TO PROCEED WITH DEFINITION PHASE OF THIS INVESTIGATION. THE GATE REQUIRED TO PROCEED FROM DEFINITION TO IMPLEMENTATION PHASE IS SELECT FOR FLIGHT BY THE HUMAN RESEARCH PROGRAM CONTROL BOARD.