FLUCTUATIONS IN THE TEMPERATURE AND POLARIZATION OF THE COSMIC MICROWAVE BACKGROUND (CMB) ENCODE A WEALTH OF INFORMATION ABOUT THE PARAMETERS OF COSMOLOGY AND FUNDAMENTAL PHYSICS. THE CHALLENGE FOR CMB SCIENTISTS HAS ALWAYS BEEN TO DETECT THESE TINY SIGNALS IN THE FACE OF POTENTIALLY OVERWHELMING STATISTICAL AND SYSTEMATIC UNCERTAINTIES. WHILE STATISTICAL UNCERTAINTIES CAN BE REDUCED BY GATHERING LARGER AND LARGER DATA-SETS REDUCING SYSTEMATIC EFFECTS REQUIRES BOTH MINIMIZING THEM IN THE DESIGN OF ANY MISSION AND MITIGATING THEM IN THE ANALYSIS OF ITS DATA. NEXT-GENERATION MISSIONS WILL ATTEMPT TO MEASURE THE ENERGY SCALE OF INFLATION FROM THE IMPRINT OF PRIMORDIAL GRAVITATIONAL WAVES IN THE B-MODE POLARIZATION OF THE CMB. AS THE FAINTEST CMB SIGNAL AT THE NANO-KELVIN LEVEL OR BELOW ITS DETECTION WILL REQUIRE BOTH THE LARGEST DATA-SETS EVER GATHERED AND THE TIGHTEST CONTROL OF SYSTEMATIC EFFECTS EVER ACHIEVED. A CRITICAL QUESTION IN THE DESIGN OF SUCH MISSIONS IS IDENTIFYING WHICH SYSTEMATIC EFFECTS CAN ALREADY BE SUFFICIENTLY MITIGATED IN SOFTWARE AND WHICH REQUIRE ADVANCEMENTS IN HARDWARE TO MEET ITS GOALS. ADDRESSING THIS QUESTION PROCEEDS IN THREE STEPS AND BUILDS ON THE CMB MISSION DATA SYNTHESIS AND REDUCTION CAPABILITIES DEVELOPED AND DEPLOYED AT SCALE IN OUR PREVIOUS APRA PROJECT. FIRSTLY WE WILL DEVELOP THE THE ALGORITHMS AND IMPLEMENTATIONS NEEDED TO MITIGATE THE KNOWN SYSTEMATIC EFFECTS TO SUFFICIENT PRECISION WITH A PARTICULAR FOCUS ON PRE-PROCESSING THE MISSION TIME STREAM DATA IN ORDER TO PRODUCE THE CLEANEST POSSIBLE SKY MAPS. SECONDLY SINCE THEIR EFFICACY WILL DEPEND ON THE DETAILS OF THE MISSION SURVEY STRATEGY WE WILL OPTIMIZE THE SURVEY PARAMETERS WITH RESPECT TO THE ABILITY TO MITIGATE SYSTEMATICS. FINALLY USING THIS MITIGATIONOPTIMIZED SURVEY STRATEGY WE WILL IDENTIFY THE SOURCES OF SYSTEMATICS RESIDUALS THAT EXCEED OUR SCIENCE THRESHOLD AND USE THEM TO PLACE REQUIREMENTS ON INSTRUMENT PERFORMANCE.