ONE OF THE RISKS OF LONG DURATION EXPLORATION MISSIONS THAT NEEDS FURTHER INVESTIGATION IS THE POTENTIAL FOR UNANTICIPATED MEDICAL EVENTS TO AFFECT CREW HEALTH AND CAPACITY IN-FLIGHT AND POTENTIALLY COMPROMISE MISSION SUCCESS. LIKE TECHNICAL PROBLEM SOLVING MEDICAL EMERGENCIES REQUIRE RAPID DIAGNOSIS OF PROBABLE CAUSE CONCURRENT TREATMENT AND CONTAINMENT OF PROBLEMS. EFFECTIVE CREW DYNAMICS ARE ESSENTIAL TO BOTH. HOWEVER WHEN THERE IS A MEDICAL EMERGENCY ONE OF THE TEAM MEMBERS IS INCAPACITATED BY THE NATURE OF THE EVENT; CREW MEMBERS MUST RAPIDLY COORDINATE THEMSELVES TO DEAL WITH AN ILL-DEFINED EVENT THAT MAY BE OUTSIDE OF THEIR PRIMARY TECHNICAL EXPERTISE AND THE IMPACT OF TIME DELAY MEANS THAT REAL-TIME COMMUNICATIONS AND DATA FLOW BETWEEN CREW AND MEDICAL EMERGENCY SPECIALISTS ON EARTH MAY NOT BE POSSIBLE. THE CENTRAL OBJECTIVE OF OUR PROPOSAL IS TO PROVIDE GUIDANCE FOR THE DEVELOPMENT OF EVIDENCE-BASED COUNTERMEASURES AGAINST THESE VULNERABILITIES. THIS IS IMPORTANT TO DETERMINE SO WE CAN ADD THE RIGHT BEHAVIORAL SKILLS TO ASTRONAUT TRAINING. WE PLAN TO IMPLEMENT THE STUDY AND MEASURE INTERACTIONS DURING A MEDICAL EMERGENCY IN A SPACE ANALOG SETTING THAT REPLICATES SOME FEATURES OF LONG-TERM ISOLATION CREW AUTONOMY AND TIME-DELAY AS EXPERIENCED ON LONG DURATION MISSIONS. WE PROPOSE TO DO THIS BY STUDYING CAPACITY TO MANAGE MEDICAL EMERGENCIES IN SPACE USING A RANGE OF METHODS. WE WILL USE HIGH FIDELITY SIMULATION TO STUDY HOW THE ASTRONAUT CREW PERFORMS TOGETHER TO RESOLVE SIMULATED MEDICAL EMERGENCIES IN A LAB SETTING. WE WILL MEASURE ADHERENCE TO KEY PROCESSES TEAM BEHAVIOR MENTAL WORKLOAD AND PHYSIOLOGICAL METRICS TO BETTER UNDERSTAND THE DEMANDS FACED BY SPACE CREW AND GROUND PERSONNEL.