WE PROPOSE TO DEVELOP A SPACECRAFT-BASED TRL6 SYSTEM FOR IN-SITU MEASUREMENT OF SOLUBLE ORGANIC AND INORGANIC ANIONS ON PLANETARY MISSIONS. THE SYSTEM WILL DETECT COMPOUNDS THAT CONTAIN KEY ELEMENTS OF LIFE (I.E. CHNOPS) OR THAT BEAR ON THE HABITABILITY POTENTIAL OF A GIVEN ENVIRONMENT (I.E. SALTS) IN A BROAD RANGE OF PLANETARY MATERIALS AT LEVELS SIGNIFICANTLY LOWER THAN PREVIOUSLY FLOWN INSTRUMENTS. THE PROPOSED DEVELOPMENT LEVERAGES AN OPEN TUBULAR LIQUID ION CHROMATOGRAPH (OTLIC) SYSTEM DEVELOPED UNDER THE PICASSO PROGRAM TO TRL 4. IN THE OTLIC SYSTEM THE STATIONARY PHASE IS A COATING ON THE WALL OF A NARROW BORE CAPILLARY THEREBY ELIMINATING THE SENSITIVE HANDLING REQUIREMENTS OF THE SEPARATION COLUMN AND PAVING THE WAY FOR A COMPACT ROBUST FLIGHT INSTRUMENT. AS PART OF THIS MATISSE PROJECT WE WILL BUILD A HIGH FIDELITY OTLIC SUBSYSTEM (ION/LIQUID CHROMATOGRAPHY FOR EXPLORATION OF SOLAR SYSTEM ILCESS) THAT ADEQUATELY ADDRESSES ALL CRITICAL SCALING ISSUES. WE WILL TEST THE SYSTEM IN A SIMULATED OPERATIONAL ENVIRONMENT (LOW PRESSURE LOW TEMPERATURE AND HIGH RADIATION) BASED ON REQUIREMENTS STATED IN THE EUROPA LANDER SCIENCE DEFINITION TEAM REPORT. AS MAIN DELIVERABLE WE WILL DEMONSTRATE NOMINAL SYSTEM OPERATION AND DETECTION OF IONIC SPECIES FROM NATURAL AND SYNTHETIC SAMPLES UNDER CRITICAL ENVIRONMENTAL CONDITIONS. THE EXIT TRL IS ESTIMATED AT 6.