MAPPING TO HRP INTEGRATED RESEARCH PLAN. OUR PROPOSAL WILL ADDRESS THE FOLLOWING SPECIFIC GAPS FOR CARDIOVASCULAR (CV) RISKS IDENTIFIED IN NASA'S HRP INTEGRATED RESEARCH PLAN (IRP) FOLLOWING RISKS AND GAP: IRP PRIMARY RISK: RISK OF CARDIOVASCULAR DISEASE AND OTHER DEGENERATIVE TISSUE EFFECTS FROM RADIATION EXPOSURE. IRP GAPS RELEVANT TO PRIMARY RISK: DEGEN-1: HOW CAN TISSUE SPECIFIC EXPERIMENTAL MODELS BE DEVELOPED FOR THE MAJOR DEGENERATIVE TISSUE RISKS INCLUDING CARDIOVASCULAR AND OTHER TISSUE SYSTEMS IN ORDER TO ESTIMATE SPACE RADIATION RISKS FOR DEGENERATIVE DISEASES? DEGEN-2: WHAT ARE THE MECHANISMS OF DEGENERATIVE TISSUES CHANGES IN THE CARDIOVASCULAR AND OTHER TISSUE SYSTEMS? WHAT SURROGATE ENDPOINTS DO THEY SUGGEST? DEGEN-3: WHAT ARE THE PROGRESSION RATES AND LATENCY PERIODS FOR RADIATION-INDUCED DEGENERATIVE DISEASES AND HOW DO PROGRESSION RATES DEPEND ON AGE SEX RADIATION TYPE OR OTHER PHYSIOLOGICAL OR ENVIRONMENTAL FACTORS?