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IN THIS PROPOSAL WE AIM TO DETERMINE THE IMPACT OF SPACE RADIATION ON CMV LATENCY REACTIVATION AND LYTIC REPLICATION. WHILE MOST STUDIES ON THIS TOPIC IN THE PAST HAVE FOCUSED ON CHANGES IN HUMAN IMMUNE SYSTEM THAT COULD INDUCE VIRUS REACTIVATION WE WILL APPROACH THIS TOPIC FROM BOTH VIRUS AND HOST STANDPOINTS. WE WILL STUDY DIFFERENCES IN CMV LATENCY AND REACTIVATION BEFORE AND AFTER RADIATION EXPOSURE AND DETERMINE IF THESE CHANGES CAN BE CORRELATED WITH SPECIFIC CHANGES IN VIRUS GENOME AND/OR TRANSCRIPTOME. ALSO BECAUSE VIRUS CONTROL DISSEMINATION AND RESOLUTION IS ULTIMATELY GOVERNED BY THE COMPETENCY OR LACK THEREOF OF THE HOST IMMUNE SYSTEM WE WILL DETERMINE THE IMPACT OF PRE-EXPOSING NK-CELLS AND T-CELLS TO SPACE RADIATION ON THEIR ABILITY TO CONTROL ACTIVE CMV INFECTIONS. IN THIS PROJECT WE WILL FOCUS ON A SINGLE VARIABLE: THE SPACE RADIATION RATHER THAN LOOKING AT MULTIPLE VARIABLES SUCH AS MICROGRAVITY PHYSICAL AND PSYCHOLOGICAL STRESSES OF SPACE TRAVEL DIET MEDICATIONS OR OTHER FACTORS ASSOCIATED WITH SPACE FLIGHT. THE OVERARCHING HYPOTHESIS IS THAT MODELED SPACE RADIATION WILL INDUCE SPECIFIC CHANGES IN CMV GENOME/TRANSCRIPTOME OR IMMUNE CONTROL OF INFECTION THAT WILL INDUCE CMV REACTIVATION AND/OR INCREASE IN VIRUS REPLICATION AND PATHOGENICITY.

$508,569FY2020National Aeronautics and Space AdministrationNASA

University Of Mississippi Medical Center, Jackson MS

Investigators

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IN THIS PROPOSAL WE AIM TO DETERMINE THE IMPACT OF SPACE RADIATION ON CMV LATENCY REACTIVATION AND LYTIC REPLICATION. WHILE MOST STUDIES ON THIS TOPIC IN THE PAST HAVE FOCUSED ON CHANGES IN HUMAN IMMUNE SYSTEM THAT COULD INDUCE VIRUS REACTIVATION WE WILL APPROACH THIS TOPIC FROM BOTH VIRUS AND HOST STANDPOINTS. WE WILL STUDY DIFFERENCES IN CMV LATENCY AND REACTIVATION BEFORE AND AFTER RADIATION EXPOSURE AND DETERMINE IF THESE CHANGES CAN BE CORRELATED WITH SPECIFIC CHANGES IN VIRUS GENOME AND/OR TRANSCRIPTOME. ALSO BECAUSE VIRUS CONTROL DISSEMINATION AND RESOLUTION IS ULTIMATELY GOVERNED BY THE COMPETENCY OR LACK THEREOF OF THE HOST IMMUNE SYSTEM WE WILL DETERMINE THE IMPACT OF PRE-EXPOSING NK-CELLS AND T-CELLS TO SPACE RADIATION ON THEIR ABILITY TO CONTROL ACTIVE CMV INFECTIONS. IN THIS PROJECT WE WILL FOCUS ON A SINGLE VARIABLE: THE SPACE RADIATION RATHER THAN LOOKING AT MULTIPLE VARIABLES SUCH AS MICROGRAVITY PHYSICAL AND PSYCHOLOGICAL STRESSES OF SPACE TRAVEL DIET MEDICATIONS OR OTHER FACTORS ASSOCIATED WITH SPACE FLIGHT. THE OVERARCHING HYPOTHESIS IS THAT MODELED SPACE RADIATION WILL INDUCE SPECIFIC CHANGES IN CMV GENOME/TRANSCRIPTOME OR IMMUNE CONTROL OF INFECTION THAT WILL INDUCE CMV REACTIVATION AND/OR INCREASE IN VIRUS REPLICATION AND PATHOGENICITY. · GrantIndex