THIS STATEMENT OF WORK ENCOMPASSES THREE PROJECTS WITH SIGNIFICANT CONTRIBUTIONS FROM DR. SUSANA ZANELLO AT IMEC USA FLORIDA. THREE PROJECTS WERE AWARDED IN RESPONSE TO THREE SEPARATE NASA RESEARCH ANNOUNCEMENT SOLICITATIONS EACH LISTED BELOW. THIS NASA GRANT WILL COVER THREE PROJECTS ALREADY UNDERWAY FOR WHICH DR. ZANELLO IS THE PRINCIPAL INVESTIGATOR EACH LISTED AND DESCRIBED INDIVIDUALLY HEREIN. PROJECT 1 TITLE: EVALUATION OF HINDLIMB SUSPENSION AS A MODEL TO STUDY OPHTHALMIC COMPLICATIONS IN MICROGRAVITY: OCULAR STRUCTURE AND FUNCTION AND ASSOCIATION WITH INTRACRANIAL PRESSURE SOLICITATION: NNJ11ZSA002NA: RESEARCH AND TECHNOLOGY DEVELOPMENT TO SUPPORT CREW HEALTH AND PERFORMANCE IN SPACE EXPLORATION MISSIONS PROJECT 2 TITLE: A GENE EXPRESSION AND HISTOLOGIC APPROACH TO THE STUDY OF CEREBROSPINAL FLUID PRODUCTION AND OUTFLOW IN HINDLIMB SUSPENDED RATS SOLICITATION: NNJ13ZSA002N-FLAGSHIP: NASA RESEARCH AND TECHNOLOGY DEVELOPMENT TO SUPPORT CREW HEALTH AND PERFORMANCE IN SPACE EXPLORATION MISSIONS PROJECT 3 TITLE: MULTIMODAL MODELING TOWARDS NONINVASIVE ASSESSMENT OF INTRACRANIAL PRESSURE IN WEIGHTLESSNESS AND BIOMARKER IDENTIFICATION OF PREDISPOSITION TO VIIP SYNDROME SOLICITATION: NNJ13ZSA002N-ILSRA: INTERNATIONAL LIFE SCIENCES RESEARCH ANNOUNCEMENT (ILSRA)