THIS GRANT IS RESPONSIVE TO THE NASA BEHAVIORAL HEALTH AND PERFORMANCE GAP (BMED5) TO FIND.INDIVIDUAL CHARACTERISTICS THAT PREDICT SUCCESSFUL ADAPTATION AND PERFORMANCE IN AN ISOLATED .CONFINED AND EXTREME ENVIRONMENT ESPECIALLY FOR LONG DURATION MISSIONS. THE PROJECT ALSO.RELATES TO HRP SLEEP GAP 4 TO IDENTIFY INDICATORS OF INDIVIDUAL SUSCEPTIBILITIES AND RESILIENCIES TO.SLEEP LOSS AND CIRCADIAN RHYTHM DISRUPTION TO AID WITH INDIVIDUALIZED COUNTERMEASURE REGIMENS .FOR AUTONOMOUS LONG DURATION AND/OR DISTANCE EXPLORATION MISSIONS. THE PROPOSAL IS ALSO.RESPONSIVE TO BMED 1 AND BMED 2 AND SLEEP GAP 2 AND SLEEP GAP 9. THE PROJECT'S RESEARCH WILL.DELIVER A COUNTERMEASURE (SET OF DIVERSE BIOMARKERS) FOR DISTINGUISHING THOSE WHO ARE MORE.RESILIENT VERSUS THOSE WHO ARE MORE SUSCEPTIBLE TO THE ADVERSE NEUROBEHAVIORAL EFFECTS OF HIGH PERFORMANCE DEMANDS AND SLEEP LOSS STRESSORS. IF VALID MARKERS OF SUCH SUSCEPTIBILITY CAN BE.FOUND IT WILL BE POSSIBLE TO OPTIMIZE AND INDIVIDUALIZE CREW RESOURCES AND MITIGATE STRESS AND.OTHER BEHAVIORAL HEALTH AND PERFORMANCE RISKS AUTONOMOUSLY DURING LONG-DURATION SPACE FLIGHT..THIS INFORMATION WOULD ALSO BE OF USE ON EARTH IN APPLIED OCCUPATIONS THAT DEMAND SIMILAR RISKS.AND STRESSORS.