THE RESEARCH OBJECTIVE OF THE PROPOSED EFFORT IS TO COUPLE FINITE ELEMENT AND MUSCULOSKELETAL MODELING TO ENABLE SIMULATION BASED DESIGN OF HUMAN EXOSUIT SYSTEMS AND TO USE THIS FRAMEWORK TO EVALUATE OPERATIONAL PERFORMANCE SENSITIVITY TO PARAMETER CHANGES. THIS WORK BRIDGES THE DOMAINS OF BIOMECHANICS HUMAN FACTORS AND COMPUTATIONAL SOLID MECHANICS TO CREATE A MODEL BASED ENGINEERING APPROACH TO ANSWERING RELEVANT RESEARCH QUESTIONS. MANY CHALLENGES EXIST IN SIMULATING THE DYNAMICS OF TIGHTLY COUPLED SYSTEMS SUCH AS EXOSKELETONS OR EXOSUITS AND HUMAN OPERATORS. THERE ARE CURRENTLY NO HIGH FIDELITY MODELS THAT ATTAIN ACCURATE REPRESENTATIONS OF BOTH A HUMAN OPERATOR AND WEARABLE DEVICE. ENABLING SYNERGISTICALLY INTEGRATED WEARABLE SYSTEM DESIGNS THAT AUGMENT PERFORMANCE REQUIRES A TOOL TO EVALUATE DYNAMIC MOBILITY AND AGILITY OF THE HUMAN SUIT SYSTEM IN PARTICULAR THE UNDERLYING HUMAN MOVEMENTS THAT GENERATE THE SUIT MOTIONS THE SURFACE INTERACTION FORCES AND DEFLECTIONS AND THE CORRESPONDING JOINT TORQUES. THIS EFFORT WILL FOCUS ON THREE AIMS THAT ARE DEMONSTRATED WITH THE APPLICATION OF EXTENDING EXPLORATION EXOSUIT MOBILITY 1 DEVELOPMENT OF A COUPLED FINITE ELEMENT AND MUSCULOSKELETAL MODELING OF THE INTEGRATED HUMAN SUIT SYSTEM 2 VALIDATION OF THE INTEGRATED HUMAN SUIT MODEL WITH COMPONENT LEVEL AND HUMAN SYSTEM EXPERIMENTAL DATA AND 3 EVALUATION OF OPERATIONAL PERFORMANCE SENSITIVITY TO CHANGES IN MATERIAL STIFFNESS MUSCLE ACTIVATION ASSUMPTIONS AND STRATEGICALLY PLACED ACTUATION. THE PROPOSED EFFORT WILL ADDRESS THE PROJECT AIMS BY IMPLEMENTING A MULTI TIERED MODEL FRAMEWORK TO CALCULATE INTERACTION FORCES BETWEEN THE HUMAN AND SUIT WITH CORRESPONDING SURFACE DEFLECTIONS AND PERTINENT JOINT TORQUES PERFORMING A HUMAN STUDY TO VALIDATE THE MODEL ASSUMPTIONS AND ANALYZING SENSITIVITY TO A SUBSET OF MODEL PARAMETERS.