THIS NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NASA RESEARCH ANNOUNCEMENT NRA JOINTLY SOLICITS PROPOSALS FOR NASA AND THE NATIONAL SPACE BIOMEDICAL RESEARCH INSTITUTE NSBRI IN SUPPORT OF THE HUMAN RESEARCH PROGRAM HRP. PROPOSALS ARE SOLICITED BY NASA IN THE AREAS OF SENSORIMOTOR MUSCLE AND BONE CARDIOVASCULAR AND MUSCULAR ENDURANCE INTERVERTEBRAL DISC DAMAGE AND ADVANCED FOOD TECHNOLOGY. PROPOSALS ARE SOLICITED BY THE NSBRI IN THE AREAS OF CARDIOVASCULAR ALTERATIONS AND SMART MEDICAL SYSTEMS AND TECHNOLOGY. PROPOSALS RESPONDING TO NASA EMPHASES AND NSBRI EMPHASES MUST BE SUBMITTED SEPARATELY AND WILL RESULT IN SEPARATE EVALUATIONS AND AWARDS. PROPOSALS SELECTED BY NASA WILL RESULT IN THE AWARD OF A NASA GRANT. PROPOSALS SELECTED BY THE NSBRI WILL RESULT IN THE AWARD OF AN NSBRI GRANT. NASA RESERVES THE RIGHT TO SELECT PROPOSALS SUBMITTED TO THE NSBRI THAT THE NSBRI DOES NOT SELECT SUCH A SELECTION WILL RESULT IN THE AWARD OF A NASA GRANT. SIMILARLY NSBRI RESERVES THE RIGHT TO SELECT PROPOSALS SUBMITTED TO NASA THAT NASA DOES NOT SELECT SUCH A SELECTION WILL RESULT IN THE AWARD OF AN NSBRI GRANT. PROPOSALS SOLICITED THROUGH THIS NRA WILL BE EVALUATED THROUGH A TWO STEP PROCESS. ONLY PROPOSERS SUBMITTING STEP L PROPOSALS DETERMINED TO BE RELEVANT WITH RESPECT TO THE RESEARCH EMPHASES OUTLINED IN SECTIONS ILA.2 AND III.A.2 OF THIS NRA WILL BE INVITED TO SUBMIT FULL STEP 2 PROPOSALS. STEP 2 PROPOSALS MUST BE COMPLIANT WITH RESPECT TO SECTION IV.B.3 OF THIS NRA OR THEY WILL BE DECLINED WITHOUT REVIEW. PROPOSALS MUST BE SUBMITTED ELECTRONICALLY. PROPOSERS WHO INTEND TO SUBMIT PROPOSALS TO THE NASA OR NSBRI RESEARCH TOPIC AREAS OF THIS NRA SHOULD USE NSPIRES FOR PROPOSAL SUBMISSION. STEP L PROPOSALS WILL BE ACCEPTED BETWEEN JULY 31 2009 AND SEPTEMBER 3 2009. STEP L PROPOSALS WILL NOT BE ACCEPTED AFTER 5 PM EASTERN TIME ON SEPTEMBER 3 2009 EXCEPT FOR AS PROVIDED IN APPENDIX A SECTION G; INVITED STEP 2 PROPOSALS WILL BE ACCEPTED BETWEEN OCTOBER 9 2009 AND DECEMBER 3 2009 STEP 2 PROPOSALS WILL NOT BE ACCEPTED AFTER 5 PM EASTERN TIME ON DECEMBER 3 2009 EXCEPT FOR AS PROVIDED IN APPENDIX A SECTION G.