THE SHIELD PROGRAM SEEKS TO DEVELOP TECHNOLOGIES THAT WILL TRANSFORM HOW THE MILITARY MANAGES AND TREATS BSI. SPECIFICALLY, SHIELD WILL DEVELOP AND DE-RISK PROPHYLAXES SO THAT THESE TECHNOLOGIES HAVE THE POTENTIAL TO BE BROADLY ADMINISTERED TO TRAUMA VICTIMS IN COMBAT CASUALTY CARE SCENARIOS. PROPHYLAXES WILL ENABLE THE HOST TO CLEAR MULTIPLE DIFFERENT BLOODBORNE FUNGAL AND BACTERIAL PATHOGENS THAT ARE PREVALENT IN BSI. THUS, SHIELD PROPHYLAXES WILL PREVENT MORBIDITY AND MORTALITY ASSOCIATED WITH BSI INCLUDING SEQUELAE ASSOCIATED WITH INVASIVE FUNGAL INFECTIONS (IFI) AND SEPSIS. FINALLY, PROPHYLACTIC COUNTERMEASURES WILL CONFER DURABLE AND SUSTAINED PROTECTION TO THE RECIPIENT AFTER TRAUMA - A CRITICAL PERIOD WHEN THEY ARE MOST SUSCEPTIBLE TO OPPORTUNISTIC INFECTION FROM FUNGI AND BACTERIA.