UNS:Collaborative Research: Coded-illumination Fourier Ptychography for High-content Multimodal Imaging

University Of Connecticut, Storrs CT

Investigators

Abstract

Abstract (Collaborative) PI: Zheng, Guoan Proposal:1510077 PI: DiMarzio, Charles Proposal: 1510280 This project will develop a new prototype microscope of ultra-high sensitivity with super-high resolution, yet with the ability to provide 3D imaging at a large field-of-view and rapid imaging. The proposal aims to develop a new type of microscopy technique, (coded-illumination Fourier ptychography), that incorporates the innovations of novel Fourier data recovery, structured illumination for tissue sectioning, multi-layer modeling, and spectrum multiplexing. Iteration across data acquisitions is used to optimize to a final image solution. Increased image dimensionality, either spectral or spatial, is a highly desired commodity. If these techniques can be made routine, then many areas of microscopy could benefit. The proposal reflects substantial outreach to women and significant educational efforts towards graduates and undergraduates. .