GOALI: DNA in Extreme Confinement

University Of Minnesota-Twin Cities, Minneapolis MN

Investigators

Abstract

The recently demonstrated ability to stretch out long segments of DNA for genomic mapping points to a need to better understand the behavior of DNA in extreme confinement. This goal of this proposal is to develop an "engineering quality" description for the equilibrium properties and dynamics of long DNA molecules under extreme confinement in a nanochannel and to compare the predictions with experimental observations generated by BNG and its technology. The success of this project can help the development of this new DNA mapping technology by providing a fundamental understanding of DNA confined in nanochannels. This is also an excellent academic-industrial partnership that can help the development of next-generation DNA sequencing and mapping technologies.