NSF/FDA SIR: Quantitative Decision Analysis and Utility Assessments for Medical Imaging Technology

University Of California-Santa Barbara, Santa Barbara CA

Investigators

Abstract

ABSTRACT #1238502 Abbey This proposal investigates the development and analysis of utility based measures of diagnostic performance for the purpose of technology evaluation, using screening mammography as an example. This approach represents an important departure from the standard analysis, which uses receiver operating characteristic (ROC) curve analysis to obtain area under the curve (AUC) as the study endpoint. The utility methods confine attention to the most relevant part of the ROC curve. This leads to a more meaningful measure of performance, and also reduces sources of extraneous variability relative to effect size, thereby leading to a more powerful statistical design of experiments.