MRI: Acquisition of an Electron Paramagnetic Resonance (EPR) Spectrometer

Carnegie Mellon University, Pittsburgh PA

Investigators

Abstract

With this award from the Major Research Instrumentation (MRI) Program, Professor Michael Hendrich from Carnegie-Mellon University will acquire an X-band electron paramagnetic resonance (EPR) spectrometer. The award will enhance research training and education at all levels, especially in areas such as (a) metal containing proteins, enzymes, and biomimetic complexes, (b) Mossbauer spectroscopy, EPR and density functional theory calculations of oxygen activating enzymes and biomimetic complexes, (c) control of metals and spin state transitions with nucleic acid duplexes and molecular complexes, (d) probing the electronic structure of quantum-sized metal nanoclusters, (e) studies of artificial water oxidation catalysts, (f) characterization of Fe(III)-tetraanionic tetra-amidomacrocyclic-ligands, (g) cobalt complexes as potential cyanide decorporating agents, (h) molybdenum enzymes and biomimetic complexes, and (i) study of a rare earth crystalline thermometer for EPR spectroscopy. An EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels at Carnegie-Mellon University as well as at the University of Pittsburgh, Duquesne University and Allegheny College.