GOALI: Nanothermite Based Micro Shockwave Generators and Nanoparticles for Targeted and Efficient Gene/Drug Delivery

University Of Missouri-Columbia, Columbia MO

Investigators

Abstract

GOALI: NANOTHERMITE BASED MICRO SHOCKWAVE GENERATORS AND NANOPARTICLES FOR TARGETED AND EFFICIENT DRUG DELIVERY The objective of this research is to develop a novel digitally controlled micro shockwave generator by integrating nanothermites with microelectromechanical systems (MEMS). The approach is based on shockwaves from redox reactions of nanothermites. The shockwaves are used to deliver genes and/or drugs into cells with high transfection efficiency and cell survival. Furthermore, organosilicate nanoparticles synthesized on site will be utilized as an effective and targeted delivery vehicle via the shockwave. Intellectual Merit. The proposed miniaturized systems will cover the large impulse range necessary for permeabilization of a variety of cells and tissues with different mechanical properties and/or environments. Unlike physical gene delivery methods which rely on bulky and expensive instrumentation or chemical delivery methods that exhibit low transfection efficiency, the proposed MEMS-based shockwave generator -- alone or in combination with nanoparticles - - will produce shockwave interactions and drug delivery at the single cell level, providing unprecedented control over cell transfection processes. Broader Impacts. The proposed research is expected to transform the study and understanding of biological processes in health and disease, and enable novel diagnostics and interventions. Educational objectives include recruitment of students from regional college programs, including those with predominantly Black and Hispanic enrollment and a summer ?Nano Camp? for high school students. Undergraduate and graduate students, particularly from rural areas of Missouri will be trained to develop leadership, ownership, mentoring, career skills and entrepreneurship to prepare them for the 21st century work force.