Acquisition of a mass spectrometer for research and teaching

Cuny City College, New York NY

Investigators

Abstract

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at CUNY City College will acquire a time-of-flight mass spectrometer. Research programs that will be supported by this instrument include a) metal catalysis and metal catalyzed synthesis of novel nucleoside entities, carcinogen-nucleoside adducts and studies on site-specifically modified DNA; b) selective vinyl and aryl fluorination, synthesis of specifically fluorinated hydrocarbons and their metabolites, studies of conformational and biological modulation by fluorine; c) fate of organic xenobiotics in the environment and elucidation of relevant reaction mechanisms; d) studies on ligand-protein interactions as well as synthetic drug-like molecules; e) structural studies of integral membrane proteins of medical relevance; and d) synthesis and studies of furanose-based novel ene-diyne antibiotic analogs. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including environmental chemistry and synthetic chemistry.