Lung Structure-Function in Mice via Acoustic Morphotometry

Trustees Of Boston University, Boston

Investigators

Abstract

0402530 Suki The main goals of this proposal are a) to develop a coherent technology that allows the assessment of the detailed physiological functioning as well as the structure of the mouse lung in a noninvasive manner, and b) to invoke these technologies to advance fundamental relations between molecular processes altering tissue composition of the emphysematous lung and degradation in function. The specific aims are: 1) To develop a method to assess and relate the structure and function of the mouse lung in a non-invasive manner. 2) To test the methods in normal, fibrotic and emphysematous lungs following pharmacological interventions. 3) To track, on an individual basis, the alterations in structure and function in a genetically modified mouse strain that develops spontaneous emphysema.