Purchase of a MALDI-TOF Mass Spectrometer

University Of Southern California, Los Angeles CA

Investigators

Abstract

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Southern California will acquire a Matrix-assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) Mass Spectrometer. This instrument will be used in a wide variety of research projects, including studies on a) the structure-function relationships in small molecule therapeutics; b) synthesis of novel macromolecules for light-harvesting and information technology applications; c) synthesis of macrocyclic and block copolymers; d) polymer electrolytes for rechargeable lithium ion batteries; d) structure, dynamics, and functions of packaging RNA; and e) analysis of silicon-based monomers and polymers. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially polymer studies and medicinal chemistry