TEMPORAL RESOLUTION &TEMPORALLY RESOLVED BRAIN ACTIVATION STUDIES IN FMRI

$0P41FY2002RRNIH

University Of Minnesota Twin Cities, Minneapolis MN

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Abstract

The temporal resolution in fMRI studies is limited not only by imaging speed but also by a relatively slow intrinsic hemodynamic response and a finite signal-to-noise ratio. The temporal characteristics have been investigated in our laboratory. To determine the upper limit of temporal resolution in a single area during repeated tasks, motor cortex activity was investigated during visually instructed finger movements. In a separate study taking advantage of the temporal resolvability of fMRI, activity in the human primary motor cortex, the premotor cortex, and the supplementary motor area during a delayed cued finger movement task was measured by functional magnetic resonance imaging. Activity during movement preparation was resolved from activity during movement execution in a single trial.

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