Purchase of an 'Exact Mass' Spectrometry System

Wayne State University, Detroit MI

Investigators

Abstract

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Wayne State University will purchase a Mass Spectrometer. This equipment will enhance research in a number of areas including 1) the development of new nickel-catalyzed reactions and the total synthesis of complex natural products; 2) the development of new metathesis-based approaches to C-glycosides; 3) the total synthesis of pharmacologically active natural products; 4) synthesis of complex carbohydrates and natural products; 5) synthesis of natural products through biosynthetic pathway engineering; and 6) the design and synthesis of enzyme and receptor inhibitors. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. It is one of the fastest growing and most widely used analytical instrumentation techniques. Because of this, it is important for undergraduate and graduate students to be exposed to the technique. Graduate students, undergraduate summer and postdocs will use this instrument for their research.