Novel Chemistry of Halogenated Cyclic Ketones

University Of Missouri-Columbia, Columbia MO

Investigators

Abstract

The foci of this research involve the preparation of of cyclopentadienones and the use of these compounds in cycloadditions and related processes. Within this context the concept of antiaromaticity-driven reactions and retro-Nazarov chemistry will be explored. An indanone synthesis, cyclopentadienone dimer photochemistry, the synthesis of eight-membered rings and the synthesis of polyenes will be carried out to develop and test the scope of the methodology. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Michael Harmata in the Department of Chemistry at the University of Missouri-Columbia. Dr. Harmata will focus his work on developing synthetic methodology using cations and cycloaddition processes. Starting with simple starting materials, complex molecules can be obtained in a quick and efficient manner. There is potential for broader impact of the work in the areas of medicinal and materials chemistry. The project also presents an excellent venue for the training of graduate students.