Synthesis of C-Aryl Glycosides and Nucleosides

Tulane University, New Orleans LA

Investigators

Abstract

Professor Li first proposes to study the synthesis of C-glycosides in water. This group will first investigate the coupling of aryl halides with aldehydes in water then move to coupling reactions involving carbohydrates. This methodology will then be applied to the synthesis of several polyhydroxylated natural products. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Chao-Jun li of the Department of Chemistry at Tulane University. Dr. Li will work on the development new carbon-carbon bond forming reactions which can be used to prepare carbohydrates in water. When developed, Dr. Li's work could be applied to the environmentally friendly syntheses of a number of biologically active molecules which contain the carbohydrate framework. Students trained during the course of this work will gain skills needed by the pharmaceutical and speciality chemicals industries.