ROTAVIRUS

$134,676P41FY2002RRNIH

Baylor College Of Medicine, Houston TX

Investigators

Linked publications & trials

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Abstract

Rotavirus is a large (dia=1000 [unreadable]) icosahedral virus composed of three capsid protein layers and 11 dsRNA segments. It is the most important cause of gastroenteritis in children accounting for over a million deaths annually. The three-dimensional structure of actively-transcribing rotavirus particles reveals that the nascent mRNA transcripts generated within the core of the virion by endogenous transcriptase complexes are translocated through the intact capsid via a system of channels at the icosahedral 5-fold axes.

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